Luminescent GdVO4:Eu3+ functionalized mesoporous silica nanoparticles for magnetic resonance imaging and drug delivery

	Luminescent GdVO4:Eu3+ functionalized mesoporous silica nanoparticles for magnetic resonance imaging and drug delivery
	Huang SS ; Cheng ZY ; Ma PA ; Kang XJ ; Dai YL ; Lin J
刊名	dalton transactions
	2013
卷号	42 期号:18 页码:6523-6530
关键词	UP-CONVERSION LUMINESCENCE CONTROLLED-RELEASE HOLLOW SPHERES GUEST MOLECULES CONTRAST AGENTS CARRIER SYSTEM PH-DRIVEN TUMOR PH HYBRID NANOCRYSTALS
ISSN号	1477-9226
通讯作者	lin j
中文摘要	luminescent gdvo4:eu3+ nanophosphor functionalized mesoporous silica nanoparticles (msn) were prepared (denoted as gdvo4:eu3+@ msn). the in vitro cytotoxicity tests show that the sample has good biocompatibility, which indicates that the nanocomposite could be a promising candidate for drug delivery. flow cytometry and confocal laser scanning microscopy (clsm) confirm that the sample can be effectively taken up by skov3 ovarian cancer cells and a549 lung adenocarcinoma cells. it was also shown that the gdvo4:eu3+@ msn brightened the t-1-weighted images and enhanced the r(1) relaxivity of water protons, which suggested that they could act as t-1 contrast agents for magnetic resonance (mr) imaging. it was found that the carriers present a ph-dependent drug release behavior for doxorubicin (dox). the composites show a red emission under uv irradiation due to the gdvo4:eu3+ nanophosphors. furthermore, the pl intensity of the composite shows correlation with the cumulative release of dox. these results suggest that the composite can potentially act as a multifunctional drug carrier system with luminescent tagging, mr imaging and ph-controlled release property for dox.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000317583000033
公开日期	2014-04-18
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/50310]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Huang SS,Cheng ZY,Ma PA,et al. Luminescent GdVO4:Eu3+ functionalized mesoporous silica nanoparticles for magnetic resonance imaging and drug delivery[J]. dalton transactions,2013,42(18):6523-6530.
APA	Huang SS,Cheng ZY,Ma PA,Kang XJ,Dai YL,&Lin J.(2013).Luminescent GdVO4:Eu3+ functionalized mesoporous silica nanoparticles for magnetic resonance imaging and drug delivery.dalton transactions,42(18),6523-6530.
MLA	Huang SS,et al."Luminescent GdVO4:Eu3+ functionalized mesoporous silica nanoparticles for magnetic resonance imaging and drug delivery".dalton transactions 42.18(2013):6523-6530.