Hollow structured upconversion luminescent NaYF4:Yb3+, Er3+ nanospheres for cell imaging and targeted anti-cancer drug delivery

	Hollow structured upconversion luminescent NaYF4:Yb3+, Er3+ nanospheres for cell imaging and targeted anti-cancer drug delivery
	Yang DM ; Kang XJ ; Ma PA ; Dai YL ; Hou ZY ; Cheng ZY ; Li CX ; Lin J
刊名	biomaterials
	2013
卷号	34 期号:5 页码:1601-1612
关键词	MESOPOROUS SILICA NANOPARTICLES PHOTODYNAMIC THERAPY MAGNETIC-RESONANCE FACILE SYNTHESIS IN-VITRO NANOCRYSTALS PARTICLES SPHERES SHELL MICROSPHERES
ISSN号	0142-9612
通讯作者	li cx
中文摘要	uniform alpha-nayf4:yb3+, er3+ nanospheres (similar to 130 nm) with mesoporous shell and hollow interior structure were synthesized by using y(oh)co3:yb3+, er3+ nanospheres (nps) as sacrificial templates via a surface-protected "etching" and hydrothermal ion-exchange process. in this process, polyethylenimine (pei) ligands played a key role in formation of the hollow structured alpha-nayf4 nanospheres, i.e., they can effectively protect the surface of the y(oh)co3 from rapid dissolution by h+. moreover, folic acid (fa), a commonly used cancer-targeting agent was conjugated on the surface of nps based on the presence of free amine groups. the as-prepared fa-modified hollow nps can be performed as anti-cancer drug carriers for the investigation of drug storage/release properties, which exhibit greater cytotoxicity than dox-loaded alpha-nayf4 nps due to the specific cell uptake by hela cells via fa receptor-mediate endocytosis. furthermore, upconversion (uc) luminescence images of fa-modified alpha-nayf4:yb3+, er3+ nps uptaken by cells shows bright green emission without background noise under 980 nm infrared laser excitation. thus, these multifunctional nanospheres combining uc luminescent property and hollow and mesoporous structure have potential for simultaneous targeted anti-cancer drug delivery and cell imaging. (c) 2012 elsevier ltd. all rights reserved.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000313929400016
公开日期	2014-04-16
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/50075]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Yang DM,Kang XJ,Ma PA,et al. Hollow structured upconversion luminescent NaYF4:Yb3+, Er3+ nanospheres for cell imaging and targeted anti-cancer drug delivery[J]. biomaterials,2013,34(5):1601-1612.
APA	Yang DM.,Kang XJ.,Ma PA.,Dai YL.,Hou ZY.,...&Lin J.(2013).Hollow structured upconversion luminescent NaYF4:Yb3+, Er3+ nanospheres for cell imaging and targeted anti-cancer drug delivery.biomaterials,34(5),1601-1612.
MLA	Yang DM,et al."Hollow structured upconversion luminescent NaYF4:Yb3+, Er3+ nanospheres for cell imaging and targeted anti-cancer drug delivery".biomaterials 34.5(2013):1601-1612.