Biodegradable pH-responsive polyacrylic acid derivative hydrogels with tunable swelling behavior for oral delivery of insulin

	Biodegradable pH-responsive polyacrylic acid derivative hydrogels with tunable swelling behavior for oral delivery of insulin
	Gao XY ; He CL ; Xiao CS ; Zhuang XL ; Chen XS
刊名	polymer
	2013
卷号	54 期号:7 页码:1786-1793
关键词	BLOCK-COPOLYMER HYDROGELS CROSS-LINKED HYDROGEL DRUG-DELIVERY SENSITIVE HYDROGELS COMPLEXATION HYDROGELS POLY(L-GLUTAMIC ACID) POLY(ACRYLIC ACID) CELL-ADHESION PROTEIN DRUGS RELEASE
ISSN号	0032-3861
通讯作者	chen xs
中文摘要	novel biodegradable and ph-sensitive hydrogels composed of four types of ph-sensitive polyacrylic acid derivatives (paad) and a biodegradable poly(l-glutamic acid) (pga) crosslinker were synthesized and characterized for oral delivery of proteins or peptides. the swelling ratios of hydrogels in buffer solutions showed a ph-dependent profile at different ph values. insulin was loaded into the hydrogels as a model protein. the in vitro drug release experiment was carried out at different ph values and the release data suggested that both the ph and the type of the aad unit played important roles in the drug release behaviors of the hydrogels. in vitro mu assay indicated that the hydrogels displayed good cyto-compatibility. after oral administration of insulin-loaded hydrogel particles to streptozotocin-induced diabetic rats at 60 iu/kg, the fasting plasma glucose level was reduced continuously to 67.4% within 7 h. these results indicated that the hydrogels are potential new vehicles for oral delivery of drugs. (c) 2013 elsevier ltd. all rights reserved.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000316303400011
公开日期	2014-04-16
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/49964]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Gao XY,He CL,Xiao CS,et al. Biodegradable pH-responsive polyacrylic acid derivative hydrogels with tunable swelling behavior for oral delivery of insulin[J]. polymer,2013,54(7):1786-1793.
APA	Gao XY,He CL,Xiao CS,Zhuang XL,&Chen XS.(2013).Biodegradable pH-responsive polyacrylic acid derivative hydrogels with tunable swelling behavior for oral delivery of insulin.polymer,54(7),1786-1793.
MLA	Gao XY,et al."Biodegradable pH-responsive polyacrylic acid derivative hydrogels with tunable swelling behavior for oral delivery of insulin".polymer 54.7(2013):1786-1793.