Electrospun hydroxyapatite grafted poly(L-lactide)/poly(lactic-co-glycolic acid) nanofibers for guided bone regeneration membrane

	Electrospun hydroxyapatite grafted poly(L-lactide)/poly(lactic-co-glycolic acid) nanofibers for guided bone regeneration membrane
	Song XF ; Ling FG ; Ma LL ; Yang CG ; Chen XS
刊名	composites science and technology
	2013
卷号	79 页码:8-14
关键词	SELF-ASSEMBLED MONOLAYERS SURFACE FUNCTIONAL-GROUPS L-LACTIC ACID PROTEIN ADSORPTION SCAFFOLDS POLYMERIZATION NANOPARTICLES DEGRADATION COMPOSITE COPOLYMER
ISSN号	0266-3538
通讯作者	chen xs
中文摘要	to create new biodegradable guided bone regeneration (gbr) membranes, the composites of hydroxyapatite grafted poly(l-lactide) (ha-g-plla) nanoparticles and poly (l-lactide-co-glycolide) (plga) were prepared by electrospinning, and their corresponding properties were evaluated including morphology, thermodynamics, mechanics, wettability, degradation, bioactivity, and biocompatibility. at 5 wt% ha-g-plla, the nanoparticles evenly distributed in the fibers and the composite fiber membranes showed higher strength properties compared to pristine plga and ha/plga. however, as the ha-g-plla content increased, the nanoparticles began to aggregate, which resulted in the deterioration of mechanics properties of the composite fiber membrane. the degradation and bioactivity of the composite fiber membrane were depended strongly on the ha-g-plla contents. with ha-g-plla contents going up, degradation rate speeded up due to the increased wettability of the composite fibers and the decreased crystallinity of plga matrix. the analysis for different soaking periods in sbf demonstrated the growth of a hydroxyapatite-like layer on the composite surfaces. the biocompatibility of the composite fiber membranes were assessed by the cell attachment. the osteoblasts adhered and spread on the composite membranes of 20 wt% ha-g-plla were higher than the other composites. these results suggested that the bioresorbable ha-g-plla/plga composite fiber membranes could be utilized for gbr therapy. (c) 2013 elsevier ltd. all rights reserved.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000318377900002
公开日期	2014-04-16
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/49904]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Song XF,Ling FG,Ma LL,et al. Electrospun hydroxyapatite grafted poly(L-lactide)/poly(lactic-co-glycolic acid) nanofibers for guided bone regeneration membrane[J]. composites science and technology,2013,79:8-14.
APA	Song XF,Ling FG,Ma LL,Yang CG,&Chen XS.(2013).Electrospun hydroxyapatite grafted poly(L-lactide)/poly(lactic-co-glycolic acid) nanofibers for guided bone regeneration membrane.composites science and technology,79,8-14.
MLA	Song XF,et al."Electrospun hydroxyapatite grafted poly(L-lactide)/poly(lactic-co-glycolic acid) nanofibers for guided bone regeneration membrane".composites science and technology 79(2013):8-14.