Monitoring the Folding of Trp-Cage Peptide by Two-Dimensional Infrared (2DIR) Spectroscopy

	Monitoring the Folding of Trp-Cage Peptide by Two-Dimensional Infrared (2DIR) Spectroscopy
	Lai ZZ ; Preketes NK ; Mukamel S ; Wang J
刊名	journal of physical chemistry b
	2013
卷号	117 期号:16 页码:4661-4669
关键词	FEMTOSECOND CORRELATION SPECTROSCOPIES AMIDE-I VIBRATIONAL EXCITONS SECONDARY STRUCTURE MOLECULAR-DYNAMICS ENERGY LANDSCAPE PROTEIN MODEL SIMULATIONS MECHANISM
ISSN号	1520-6106
通讯作者	wang j
中文摘要	protein folding is one of the most fundamental problems in modern molecular biology. uncovering the detailed folding mechanism requires methods that can monitor the structures at high temporal and spatial resolution. two-dimensional infrared (2dir) spectroscopy is a new tool for studying protein structures and dynamics with high time resolution. using atomistic molecular dynamics simulations, we illustrate the folding process of trp-cage along the dominant pathway on the free energy landscape by analyzing nonchiral and chiral coherent 2dir spectra along the pathway. isotope labeling is used to reveal residue-specific information. we show that the high resolution structural sensitivity of 2dir can differentiate the ensemble evolution of protein and thus provides a microscopic picture of the folding process.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000318211600061
公开日期	2014-04-16
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/49896]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Lai ZZ,Preketes NK,Mukamel S,et al. Monitoring the Folding of Trp-Cage Peptide by Two-Dimensional Infrared (2DIR) Spectroscopy[J]. journal of physical chemistry b,2013,117(16):4661-4669.
APA	Lai ZZ,Preketes NK,Mukamel S,&Wang J.(2013).Monitoring the Folding of Trp-Cage Peptide by Two-Dimensional Infrared (2DIR) Spectroscopy.journal of physical chemistry b,117(16),4661-4669.
MLA	Lai ZZ,et al."Monitoring the Folding of Trp-Cage Peptide by Two-Dimensional Infrared (2DIR) Spectroscopy".journal of physical chemistry b 117.16(2013):4661-4669.