The synthesis, deprotection and properties of poly(gamma-benzyl-l-glutamate)

	The synthesis, deprotection and properties of poly(gamma-benzyl-l-glutamate)
	Han JD ; Ding JX ; Wang ZC ; Yan SF ; Zhuang XL ; Chen XS ; Yin JB
刊名	science china-chemistry
	2013
卷号	56 期号:6 页码:729-738
关键词	ACID-N-CARBOXYANHYDRIDES HYDROPHILIC BLOCK-COPOLYMERS MOLECULAR-WEIGHT POLY(L-GLUTAMIC ACID) CONTROLLED POLYMERIZATION NCA POLYMERIZATION POLYPEPTIDE DRUG MICELLES INITIATION
ISSN号	1674-7291
通讯作者	chen xs
中文摘要	diethylamine, di-n-hexylamine, dicyclohexylamine and triethylamine have been used as initiators for the ring-opening polymerization of gamma-benzyl-l-glutamate n-carboxyanhydride (blg nca) to synthesize poly(gamma-benzyl-l-glutamate) (pblg). the relationship between the molecular weight of pblg and the molar ratio of monomer and initiator was studied. with dicyclohexylamine as initiator, the influence of monomer concentration, and reaction temperature and time on the polymerization of blg nca was examined. three reagents were used for the deprotection of benzyl groups in pblg, including hydrobromic acid/acetic acid (33 wt.%), naoh aqueous solution and trimethylsilyl iodide (tmsi). through examining the molecular weight of plga obtained using different deprotection methods, it was revealed that tmsi could minimize chain cleavage in the process of deprotection and retain the degree of polymerization. the biocompatibilities of pblg obtained using different initiators were evaluated by a live/dead assay against l929 fibroblast cells. the in vitro cytotoxicities of plga obtained using different deprotecting agents were evaluated by a methyl thiazolyl tetrazolium assay. the results revealed that both pblg and plga exhibited good biocompatibilities.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000319775900005
公开日期	2014-04-15
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/49832]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Han JD,Ding JX,Wang ZC,et al. The synthesis, deprotection and properties of poly(gamma-benzyl-l-glutamate)[J]. science china-chemistry,2013,56(6):729-738.
APA	Han JD.,Ding JX.,Wang ZC.,Yan SF.,Zhuang XL.,...&Yin JB.(2013).The synthesis, deprotection and properties of poly(gamma-benzyl-l-glutamate).science china-chemistry,56(6),729-738.
MLA	Han JD,et al."The synthesis, deprotection and properties of poly(gamma-benzyl-l-glutamate)".science china-chemistry 56.6(2013):729-738.