Polypeptide/Doxorubicin Hydrochloride Polymersomes Prepared Through Organic Solvent-free Technique as a Smart Drug Delivery Platform

	Polypeptide/Doxorubicin Hydrochloride Polymersomes Prepared Through Organic Solvent-free Technique as a Smart Drug Delivery Platform
	Li MQ ; Lv SX ; Tang ZH ; Song WT ; Yu HY ; Sun H ; Liu HY ; Chen XS
刊名	macromolecular bioscience
	2013
卷号	13 期号:9 页码:1150-1162
关键词	CROSS-LINKED MICELLES CANCER-CELLS INTRACELLULAR RELEASE POLYPEPTIDE NANOGELS COPOLYMER MICELLES ACID NANOPARTICLES TRIGGERED RELEASE CLICK CHEMISTRY BLOCK-COPOLYMER THIOL-YNE
ISSN号	1616-5187
通讯作者	liu hy
中文摘要	rapid and efficient side-chain functionalization of polypeptide with neighboring carboxylgroups is achieved via the combination of ring-opening polymerization and subsequent thiol-yne click chemistry. the spontaneous formation of polymersomes with uniform size is found to occur in aqueous medium via electrostatic interaction between the anionic polypeptide and cationic doxorubicin hydrochloride (doxhcl). the polymersomes are taken up by a549 cells via endocytosis, with a slightly lower cytotoxicity compared with free doxhcl. moreover, the drug-loaded polymersomes exhibit the enhanced therapeutic efficacy, increase apoptosis in tumor tissues, and reduce systemic toxicity in nude mice bearing a549 lung cancer xenograft, in comparison with free doxhcl.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000327882700003
公开日期	2014-04-15
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/49636]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Li MQ,Lv SX,Tang ZH,et al. Polypeptide/Doxorubicin Hydrochloride Polymersomes Prepared Through Organic Solvent-free Technique as a Smart Drug Delivery Platform[J]. macromolecular bioscience,2013,13(9):1150-1162.
APA	Li MQ.,Lv SX.,Tang ZH.,Song WT.,Yu HY.,...&Chen XS.(2013).Polypeptide/Doxorubicin Hydrochloride Polymersomes Prepared Through Organic Solvent-free Technique as a Smart Drug Delivery Platform.macromolecular bioscience,13(9),1150-1162.
MLA	Li MQ,et al."Polypeptide/Doxorubicin Hydrochloride Polymersomes Prepared Through Organic Solvent-free Technique as a Smart Drug Delivery Platform".macromolecular bioscience 13.9(2013):1150-1162.