Effective Tumor Treatment by VEGF siRNA Complexed with Hydrophobic Poly(Amino Acid)-Modified Polyethylenimine

	Effective Tumor Treatment by VEGF siRNA Complexed with Hydrophobic Poly(Amino Acid)-Modified Polyethylenimine
	Chen J ; Tian HY ; Dong X ; Guo ZP ; Jiao ZX ; Li FF ; Kano A ; Maruyama A ; Chen XS
刊名	macromolecular bioscience
	2013
卷号	13 期号:10 页码:1438-1446
关键词	ENDOTHELIAL GROWTH-FACTOR AMINO-ACID SEGMENT HYPERBRANCHED PEI GENE DELIVERY IN-VITRO MICELLES RNA CANCER PBLG NANOPARTICLES
ISSN号	1616-5187
通讯作者	tian hy
中文摘要	two copolymers are designed and synthesised for sirna delivery based on polyethylenimine by grafting hydrophilic acrylamide segments and hydrophobic poly(gamma-benzyl l-glutamate). the amphiphilic pei-pblg/sirna complex demonstrates high gene silencing efficiency in the absence or presence of 10 vol% and 50 vol% sera in vitro. the anti-tumor effects in vivo are evaluated in luciferase-bearing mice expressing ct26 tumors. pei-pblg/sivegf complex provides a higher and more sustained suppressive effect by reducing vegf mrna expression in the tumors, leading to higher tumor growth inhibition efficacy. further studies on the potential use of the pei-pblg carrier system in mediating the silencing of genes other than vegf or in other tumor models are recommended.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000328744300018
公开日期	2014-04-15
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/49555]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Chen J,Tian HY,Dong X,et al. Effective Tumor Treatment by VEGF siRNA Complexed with Hydrophobic Poly(Amino Acid)-Modified Polyethylenimine[J]. macromolecular bioscience,2013,13(10):1438-1446.
APA	Chen J.,Tian HY.,Dong X.,Guo ZP.,Jiao ZX.,...&Chen XS.(2013).Effective Tumor Treatment by VEGF siRNA Complexed with Hydrophobic Poly(Amino Acid)-Modified Polyethylenimine.macromolecular bioscience,13(10),1438-1446.
MLA	Chen J,et al."Effective Tumor Treatment by VEGF siRNA Complexed with Hydrophobic Poly(Amino Acid)-Modified Polyethylenimine".macromolecular bioscience 13.10(2013):1438-1446.