LC-MS Guided Isolation of (+/-)-Sweriledugenin A, a Pair of Enantiomeric Lactones, from Swertia leducii | |
Geng, Chang-An; Chen, Xing-Long; Zhou, Ning-Jia; Chen, Hao; Ma, Yun-Bao; Huang, Xiao-Yan; Zhang, Xue-Mei; Chen, Ji-Jun | |
刊名 | ORGANIC LETTERS |
2014-01-17 | |
卷号 | 16期号:2页码:370-373 |
关键词 | ALKALOIDS |
ISSN号 | 1523-7060 |
通讯作者 | Chen,JJ (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Peoples R China. ; chenjj@mail.kib.ac.cn |
英文摘要 | (+/-)-Sweriledugenin A, a pair of novel enantiomeric lactones, were isolated from Swertia leducii under the guidance of LC-MS investigation. The enantiomeric separation was achieved by HPLC on a chiral column. Their structures were determined by extensive NMR spectra, X-ray, and quantum calculations. (+)-Sweriledugenin A and (-)-sweriledugenin A showed activities inhibiting HBV DNA replication with the IC50 values of 36.86 and 26.55 mu M on the HepG 2.2.15 cell line in vitro. |
学科主题 | Chemistry, Organic |
类目[WOS] | Chemistry, Organic |
研究领域[WOS] | Chemistry |
关键词[WOS] | ALKALOIDS |
收录类别 | SCI ; IC |
资助信息 | National Science Foundation of China for Distinguished Young Scholars [81025023]; National Natural Science Foundation of China and Yunnan Province [U0832603]; West Light Foundation of the Chinese Academy of Sciences; International Foundation for Science in Sweden [F/5202-1]; Youth Innovation Promotion Association, CAS |
语种 | 英语 |
WOS记录号 | WOS:000330098400012 |
公开日期 | 2014-04-09 |
内容类型 | 期刊论文 |
源URL | [http://ir.kib.ac.cn/handle/151853/17945] |
专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
作者单位 | Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China |
推荐引用方式 GB/T 7714 | Geng, Chang-An,Chen, Xing-Long,Zhou, Ning-Jia,et al. LC-MS Guided Isolation of (+/-)-Sweriledugenin A, a Pair of Enantiomeric Lactones, from Swertia leducii[J]. ORGANIC LETTERS,2014,16(2):370-373. |
APA | Geng, Chang-An.,Chen, Xing-Long.,Zhou, Ning-Jia.,Chen, Hao.,Ma, Yun-Bao.,...&Chen, Ji-Jun.(2014).LC-MS Guided Isolation of (+/-)-Sweriledugenin A, a Pair of Enantiomeric Lactones, from Swertia leducii.ORGANIC LETTERS,16(2),370-373. |
MLA | Geng, Chang-An,et al."LC-MS Guided Isolation of (+/-)-Sweriledugenin A, a Pair of Enantiomeric Lactones, from Swertia leducii".ORGANIC LETTERS 16.2(2014):370-373. |
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