Angustifonines A and B, Cytotoxic Bisindole Alkaloids from Bousigonia angustifolia

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Angustifonines A and B, Cytotoxic Bisindole Alkaloids from Bousigonia angustifolia
	Fu, Yan-hui1,2 ; Di, Ying-tong1 ; He, Hong-ping 1; Li, Shun-lin 1; Zhang, Yu1 ; Hao, Xiao-jiang1
刊名	JOURNAL OF NATURAL PRODUCTS
	2014
卷号	77 期号:1 页码:57-62
关键词	MAGNETIC-RESONANCE-SPECTROSCOPY NATURALLY-OCCURRING SUBSTANCES ASPIDOSPERMANE-TYPE ALKALOIDS CATHARANTHUS-ROSEUS MELODINUS-SUAVEOLENS HUNTERIA-EBURNEA INDOLE ALKALOIDS VINCA ALKALOIDS NEW-CALEDONIA PLANTS
ISSN号	0163-3864
通讯作者	Zhang,Y (reprint author),Chinese Acad Sci,Kunming Inst Bot,State Key Lab Phytochem & Plant Resources West Ch,Kunming 650201,Yunnan,Peoples R China. ; zhangyu@mail.kib.ac.cn ; haoxj@mail.kib.ac.cn
英文摘要	Two new bisindole alkaloids, angustifonines A (1) and B (2), comprising the union of a rearranged monoterpenoid quinoline and an aspidospermine alkaloid, as well as 27 known indole alkaloids were isolated from the twigs and leaves of Bousigonia angustifolia. Their structures and absolute configurations were elucidated by a combination of MS, NMR, and computational methods. Angustifonines A and B exhibited cytotoxicity against various human cancer cell lines with IC50 values of 2.71-16.22 mu M. A possible biosynthesis pathway toward the new bisindole alkaloids 1 and 2 is presented.
学科主题	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
类目[WOS]	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]	Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]	MAGNETIC-RESONANCE-SPECTROSCOPY ; NATURALLY-OCCURRING SUBSTANCES ; ASPIDOSPERMANE-TYPE ALKALOIDS ; CATHARANTHUS-ROSEUS ; MELODINUS-SUAVEOLENS ; HUNTERIA-EBURNEA ; INDOLE ALKALOIDS ; VINCA ALKALOIDS ; NEW-CALEDONIA ; PLANTS
收录类别	SCI ; IC
资助信息	National Natural Science Foundation of China [31100259]; National Basic Research Program of China [2009CB522303]
语种	英语
WOS记录号	WOS:000330336800010
公开日期	2014-04-09
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/17926]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Fu, Yan-hui,Di, Ying-tong,He, Hong-ping,et al. Angustifonines A and B, Cytotoxic Bisindole Alkaloids from Bousigonia angustifolia[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(1):57-62.
APA	Fu, Yan-hui,Di, Ying-tong,He, Hong-ping,Li, Shun-lin,Zhang, Yu,&Hao, Xiao-jiang.(2014).Angustifonines A and B, Cytotoxic Bisindole Alkaloids from Bousigonia angustifolia.JOURNAL OF NATURAL PRODUCTS,77(1),57-62.
MLA	Fu, Yan-hui,et al."Angustifonines A and B, Cytotoxic Bisindole Alkaloids from Bousigonia angustifolia".JOURNAL OF NATURAL PRODUCTS 77.1(2014):57-62.