Secondary Metabolites from Penicillium pinophilum SD-272, a Marine Sediment-Derived Fungus

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 海岸带生物学与生物资源利用重点实验室 > 海岸带生物学与生物资源利用所重点实验室

	Secondary Metabolites from Penicillium pinophilum SD-272, a Marine Sediment-Derived Fungus
	Wang, Ming-Hui 1,2; Li, Xiao-Ming 1; Li, Chun-Shun 1; Ji, Nai-Yun3 ; Wang, Bin-Gui 1
刊名	MARINE DRUGS
	2013-06-01
卷号	11 期号:6 页码:2230-2238
关键词	sediment Penicillium pinophilum secondary metabolite brine shrimp lethality
通讯作者	Ji, NY (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Chunhui Rd 17, Yantai 264003, Peoples R China. wangmh29@yahoo.cn
产权排序	[Wang, Ming-Hui; Li, Xiao-Ming; Li, Chun-Shun; Wang, Bin-Gui] Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China; [Wang, Ming-Hui] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Ji, Nai-Yun] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China
中文摘要	Two new secondary metabolites, namely, pinodiketopiperazine A (1) and 6,7-dihydroxy-3-methoxy-3-methylphthalide (2), along with alternariol 2,4-dimethyl ether (3) and L-5-oxoproline methyl ester (4), which were isolated from a natural source for the first time but have been previously synthesized, were characterized from the marine sediment-derived fungus Penicillium pinophilum SD-272. In addition, six known metabolites (5-10) were also identified. Their structures were elucidated by analysis of the NMR and mass spectroscopic data. The absolute configuration of compound 1 was determined by experimental and calculated ECD spectra. Compound 2 displayed potent brine shrimp (Artemia salina) lethality with LD50 11.2 mu M.
英文摘要	Two new secondary metabolites, namely, pinodiketopiperazine A (1) and 6,7-dihydroxy-3-methoxy-3-methylphthalide (2), along with alternariol 2,4-dimethyl ether (3) and L-5-oxoproline methyl ester (4), which were isolated from a natural source for the first time but have been previously synthesized, were characterized from the marine sediment-derived fungus Penicillium pinophilum SD-272. In addition, six known metabolites (5-10) were also identified. Their structures were elucidated by analysis of the NMR and mass spectroscopic data. The absolute configuration of compound 1 was determined by experimental and calculated ECD spectra. Compound 2 displayed potent brine shrimp (Artemia salina) lethality with LD50 11.2 mu M.
学科主题	Chemistry ; Medicinal
研究领域[WOS]	Pharmacology & Pharmacy
关键词[WOS]	NATURAL-PRODUCTS ; AMINO-ACIDS ; DERIVATIVES ; ALTERNARIOL ; ALKALOIDS ; ETHER
收录类别	SCI
资助信息	Ministry of Science and Technology [2013AA092901, 2010CB833802]; National Natural Science Foundation of China [31270403]
语种	英语
WOS记录号	WOS:000320772100028
公开日期	2014-04-04
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/6786]
专题	烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Wang, Ming-Hui,Li, Xiao-Ming,Li, Chun-Shun,et al. Secondary Metabolites from Penicillium pinophilum SD-272, a Marine Sediment-Derived Fungus[J]. MARINE DRUGS,2013,11(6):2230-2238.
APA	Wang, Ming-Hui,Li, Xiao-Ming,Li, Chun-Shun,Ji, Nai-Yun,&Wang, Bin-Gui.(2013).Secondary Metabolites from Penicillium pinophilum SD-272, a Marine Sediment-Derived Fungus.MARINE DRUGS,11(6),2230-2238.
MLA	Wang, Ming-Hui,et al."Secondary Metabolites from Penicillium pinophilum SD-272, a Marine Sediment-Derived Fungus".MARINE DRUGS 11.6(2013):2230-2238.