Phthalates exposure of Chinesereproductiveagecouples and its effect on male semen quality, a primary study | |
Liangpo Liu ; Huaqiong Bao ; Feng Liu ; Jie Zhang ; Heqing Shen | |
刊名 | Environment International
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2012 | |
卷号 | 42期号:/页码:78-83 |
中文摘要 | Phthalates are suspected of having adverse effects on androgen-regulated reproductive development in animals and may be toxic for human sperm. The purposes of our study were to investigate the general exposure of a Chinese reproductive age cohort to these ubiquitous pollutants and to assess their potential effect on semen quality. Six phthalate metabolites, monomethyl phthalate (MMP), monoethyl phthalate (MEP), monobutyl phthalate (MBP), monobenzyl phthalate (MBzP), mono-2-ethylhexyl phthalate (MEHP), and mono-2-ethyl-5-oxohexyl phthalate (MEOHP) were measured in spot urines of 150 individuals recruited from a Chongqing, China, reproductive institute. The questionnaire and clinical data were evaluated, and the correlations of phthalate exposure and semen qualities like semen volume, sperm concentration, motility and sperm motion parameters, were determined by multiple logistic regression analysis. The creatinine adjusted average concentrations for MMP, MEP, MBP, MBzP, MEHP and MEOHP were 41.3, 300, 41.0, 0.78, 2.99 and 3.90 μg/g, respectively. After adjustment for age, body mass index (BMI), abstinence, smoking, drinking, and education, there was a borderline-significant dose–response relationship between MBP and sperm concentration, with odd ratios (ORs) 1.0, 6.8 and 12.0 for increasing exposure tertiles (p = 0.05). Although the dose–response relationships for MMP and MEP versus sperm concentration were not significant, a significant positive correlation between MEP and straight-line velocity of sperm motion was observed. The present data may imply some effects of phthalate exposure on semen. However, due to the small sample size, our finding needs to be confirmed on a larger population. |
收录类别 | SCI |
公开日期 | 2013-09-05 |
内容类型 | 期刊论文 |
源URL | [http://124.16.167.195/handle/335003/1218] ![]() |
专题 | 城市环境研究所_环境污染物的人群暴露与健康效应研究组_期刊论文 |
推荐引用方式 GB/T 7714 | Liangpo Liu,Huaqiong Bao,Feng Liu,et al. Phthalates exposure of Chinesereproductiveagecouples and its effect on male semen quality, a primary study[J]. Environment International,2012,42(/):78-83. |
APA | Liangpo Liu,Huaqiong Bao,Feng Liu,Jie Zhang,&Heqing Shen.(2012).Phthalates exposure of Chinesereproductiveagecouples and its effect on male semen quality, a primary study.Environment International,42(/),78-83. |
MLA | Liangpo Liu,et al."Phthalates exposure of Chinesereproductiveagecouples and its effect on male semen quality, a primary study".Environment International 42./(2012):78-83. |
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