Impact of PEGylation on the biological effects and light heat conversion efficiency of gold nanoshells on silica nanorattles

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	Impact of PEGylation on the biological effects and light heat conversion efficiency of gold nanoshells on silica nanorattles
	Liu, HY ; Liu, TL ; Wang, H ; Li, LL ; Tan, LF ; Fu, CH ; Nie, GJ ; Chen, D ; Tang, FQ
刊名	BIOMATERIALS
	2013
卷号	34 期号:28 页码:6967
关键词	Nanomedicine PEGylation Gold nanoshells Light heat conversion efficiency Biological effects
ISSN号	0142-9612
通讯作者	Tang, FQ (reprint author), Chinese Acad Sci, Tech Inst Phys & Chem, Lab Controllable Preparat & Applicat Nanomat, 29 East Rd Zhongguancun, Beijing 100190, Peoples R China.
中文摘要	As an excellent photothermal agent candidate, gold nanoshells have attracted a great deal of attention, but the influences of PEGylation on their biological effects and light heat conversion efficiency remain unclear. Here we investigate the influences of PEGylation density on the gold nanoshells on silica nanorattles (GSNPs) to their biological effects, including their cellular uptake, "corona" of biological macromolecules they are covered with, in vivo biodistribution and toxicities, and their in vitro and in vivo light heat conversion efficiency. The results suggest PEGylation obviously impacts the uptake patterns of GSNPs. Less-density PEGylated GSNPs show enhanced cellular uptake caused by the high dose exposure on cell surface due to their rapid aggregation. High-density PEGylated GSNPs show advantages in less toxicity for suppression of aggregation of GSNPs, avoidance of RES, good enhanced permeability and retention (EPR) effect of cancerous tumors, especially the enhanced light heat conversion efficiency in vivo. Less or insufficient PEGylation may induce in vivo toxicity. This study highlights the need to study the effect of PEGylation for near infrared (NIR) light absorbing nanoparticles to predict the effects and safety of nanotherapeutics. (C) 2013 Elsevier Ltd. All rights reserved.
资助信息	National Natural Science Foundation of China [31271075, 81171454, 31270022, 81201 814]; Beijing Nova Program [Z111103054511113]
语种	英语
公开日期	2014-01-16
内容类型	期刊论文
源URL	[http://ir.iphy.ac.cn/handle/311004/57098]
专题	物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文
推荐引用方式 GB/T 7714	Liu, HY,Liu, TL,Wang, H,et al. Impact of PEGylation on the biological effects and light heat conversion efficiency of gold nanoshells on silica nanorattles[J]. BIOMATERIALS,2013,34(28):6967.
APA	Liu, HY.,Liu, TL.,Wang, H.,Li, LL.,Tan, LF.,...&Tang, FQ.(2013).Impact of PEGylation on the biological effects and light heat conversion efficiency of gold nanoshells on silica nanorattles.BIOMATERIALS,34(28),6967.
MLA	Liu, HY,et al."Impact of PEGylation on the biological effects and light heat conversion efficiency of gold nanoshells on silica nanorattles".BIOMATERIALS 34.28(2013):6967.