Magnetization behavior and magnetic viscosity in nanostructured PrCo(4.5)C(0.5) ribbons

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	Magnetization behavior and magnetic viscosity in nanostructured PrCo(4.5)C(0.5) ribbons
	Yang, B ; Shen, BG ; Zhao, TY ; Sun, JR
刊名	JOURNAL OF APPLIED PHYSICS
	2008
卷号	103 期号:12
关键词	PERMANENT-MAGNETS ENERGY
ISSN号	0021-8979
通讯作者	Shen, BG: Chinese Acad Sci, Inst Phys, State Key Lab Magnetism, Beijing 100190, Peoples R China.
中文摘要	RecQ family helicases, functioning as caretakers of genomic integrity, contain a zinc-binding motif which is highly conserved among these helicases, but does not have a substantial structural similarity with any other known zinc-finger folds. In the present study, we show that a truncated variant of the human RECQ5 beta helicase comprised of the conserved helicase domain only, a splice variant named RECQ5 alpha, possesses neither ATPase nor DNA-unwinding activities, but surprisingly displays a strong strand-annealing activity. In contrast, fragments of RECQ5 beta including the intact zinc-binding motif, which is located immediately downstream of the helicase domain, exhibit much reduced strand-annealing activity but are proficient in DNA unwinding. Quantitative measurements indicate that the regulatory role of the zinc-binding motif is achieved by enhancing the DNA-binding affinity of the enzyme. The novel intramolecular modulation of RECQ5 catalytic activity mediated by the zinc-binding motif may represent a universal regulation mode for all RecQ family helicases.
收录类别	SCI
语种	英语
公开日期	2013-09-18
内容类型	期刊论文
源URL	[http://ir.iphy.ac.cn/handle/311004/41576]
专题	物理研究所_物理所公开发表论文_物理所公开发表论文_期刊论文
推荐引用方式 GB/T 7714	Yang, B,Shen, BG,Zhao, TY,et al. Magnetization behavior and magnetic viscosity in nanostructured PrCo(4.5)C(0.5) ribbons[J]. JOURNAL OF APPLIED PHYSICS,2008,103(12).
APA	Yang, B,Shen, BG,Zhao, TY,&Sun, JR.(2008).Magnetization behavior and magnetic viscosity in nanostructured PrCo(4.5)C(0.5) ribbons.JOURNAL OF APPLIED PHYSICS,103(12).
MLA	Yang, B,et al."Magnetization behavior and magnetic viscosity in nanostructured PrCo(4.5)C(0.5) ribbons".JOURNAL OF APPLIED PHYSICS 103.12(2008).