Lingzhiols, Unprecedented Rotary Door-Shaped Meroterpenoids as Potent and Selective Inhibitors of p-Smad3 from Ganoderma lucidum

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	Lingzhiols, Unprecedented Rotary Door-Shaped Meroterpenoids as Potent and Selective Inhibitors of p-Smad3 from Ganoderma lucidum
	Yan, Yong-Ming 1,3; Ai, Jun 2; Zhou, Li-Li 2; Chung, Arthur C. K.4; Li, Rong4 ; Nie, Jing 2; Fang, Ping 1; Wang, Xin-Long 1; Luo, Jie 1; Hu, Qun 1
刊名	ORGANIC LETTERS
	2013-11-01
卷号	15 期号:21 页码:5488-5491
关键词	DIABETIC-NEPHROPATHY HIGH-GLUCOSE MESANGIAL CELLS UP-REGULATION EXPRESSION ACTIVATION PATHWAYS
ISSN号	1523-7060
通讯作者	Hou,FF (reprint author),Southern Med Univ,Nanfang Hosp,Educ Minist,Div Nephrol,Key Lab Organ Failure Res,Guangzhou 510515,Guangdong,Peoples R China.,ffhouguangzhou@163.com ; yxcheng@mail.kib.ac.cn
英文摘要	(+)-Lingzhiol and (-)-lingzhiol, a pair of rotary door-shaped meroterpenoidal enantiomers, were isolated from Ganoderma lucidum. Their structures were identified by spectroscopic methods and X-ray diffraction crystallography. Lingzhiol bears an unusual 5/5/6/6 ring system characteristic of sharing a C-3'-C-7' axis. Biological evaluation showed that (+)-lingzhiol or ()-lingzhiol could selectively inhibit the phosphorylation of Smad3 in TGF-beta 1-induced rat renal proximal tubular cells and activate Nrf2/Keap1 in mesangial cells under diabetic conditions.
学科主题	Chemistry
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Chemistry, Organic
研究领域[WOS]	Chemistry
关键词[WOS]	DIABETIC-NEPHROPATHY ; HIGH-GLUCOSE ; MESANGIAL CELLS ; UP-REGULATION ; EXPRESSION ; ACTIVATION ; PATHWAYS
收录类别	SCI ; IC
资助信息	NSFC-Joint Foundation of Yunnan Province [U1202222];State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany [P2013-ZZ03];Research Grant Council of Hong Kong [GRF 463612]
语种	英语
WOS记录号	WOS:000326615100024
公开日期	2014-01-13
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/17415]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Southern Med Univ, Nanfang Hosp, Educ Minist, Div Nephrol,Key Lab Organ Failure Res, Guangzhou 510515, Guangdong, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China
推荐引用方式 GB/T 7714	Yan, Yong-Ming,Ai, Jun,Zhou, Li-Li,et al. Lingzhiols, Unprecedented Rotary Door-Shaped Meroterpenoids as Potent and Selective Inhibitors of p-Smad3 from Ganoderma lucidum[J]. ORGANIC LETTERS,2013,15(21):5488-5491.
APA	Yan, Yong-Ming.,Ai, Jun.,Zhou, Li-Li.,Chung, Arthur C. K..,Li, Rong.,...&Cheng, Yong-Xian.(2013).Lingzhiols, Unprecedented Rotary Door-Shaped Meroterpenoids as Potent and Selective Inhibitors of p-Smad3 from Ganoderma lucidum.ORGANIC LETTERS,15(21),5488-5491.
MLA	Yan, Yong-Ming,et al."Lingzhiols, Unprecedented Rotary Door-Shaped Meroterpenoids as Potent and Selective Inhibitors of p-Smad3 from Ganoderma lucidum".ORGANIC LETTERS 15.21(2013):5488-5491.