Proanthocyanidins from Spenceria ramalana and Their Effects on AGE Formation in Vitro and Hyaloid-Retinal Vessel Dilation in Larval Zebrafish in Vivo

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 中国科学院东亚植物多样性与生物地理学重点实验室

	Proanthocyanidins from Spenceria ramalana and Their Effects on AGE Formation in Vitro and Hyaloid-Retinal Vessel Dilation in Larval Zebrafish in Vivo
	Lee, Ik-Soo 1; Yu, Song Yi 1; Jung, Seung-Hyun 1; Lee, Yu-Ri 1; Lee, Yun Mi 1; Kim, Joo-Hwan 2; Sun, Hang3 ; Kim, Jin Sook 1
刊名	JOURNAL OF NATURAL PRODUCTS
	2013-10-01
卷号	76 期号:10 页码:1881-1888
关键词	A-TYPE PROANTHOCYANIDINS PRUNUS-ARMENIACA ROOTS END-PRODUCTS AGES CIRCULAR-DICHROISM PROTEIN GLYCATION PEANUT SKINS FLAVONOIDS TANNINS
ISSN号	0163-3864
通讯作者	Kim,JS (reprint author),Korea Inst Oriental Med,Herbal Med Res Div,KM Based Herbal Drug Res Grp,Taejon 305811,South Korea.,jskim@kiom.re.kr
英文摘要	Three new A-type proanthocyanidins (1-3), ent-epiafzelechin-(2 alpha -> O -> 7,4 alpha -> 8)-ent-afzelechin 3'-O-beta-D-glycopyranoside (1), ent-epiafzelechin-(2 alpha -> O -> 7,4 alpha -> 8)-ent-epiafzelechin-(2 alpha -> O -> 7,4 alpha -> 8)-ent-afzelechin (2), and ent-epiafzelechin-(2 alpha -> O -> 7,4 alpha -> 8) -ent-epiafzelechin-(2 alpha -> O -> 7,4 alpha -> 8)-ent-afzelechin (3), and three known compounds (4-6) were isolated from the whole plant of Spenceria ramalana. The structures of the new proanthocyanidins were established by spectroscopic and chemical studies. The inhibitory effects of compounds 1-6 on the formation of advanced glycation end products were examined in vitro. Compounds 3 and 6 showed the strongest inhibition, with IC50 values of 17.4 +/- 0.5 and 14.1 +/- 1.6 mu M, respectively. The effects of these isolates on the dilation of hyaloid-retinal vessels induced by high glucose (HG) in larval zebrafish were also investigated. Compound 3 reduced the dilation of HG-induced hyaloid-retinal vessels most effectively. This compound reduced the diameters of HG-induced hyaloid-retinal vessels by about 157.7% and 164.1% at 10 and 20 mu M, respectively, versus the HG-treated control group.
学科主题	Plant Sciences ; Pharmacology & Pharmacy
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]	Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]	A-TYPE PROANTHOCYANIDINS ; PRUNUS-ARMENIACA ROOTS ; END-PRODUCTS AGES ; CIRCULAR-DICHROISM ; PROTEIN GLYCATION ; PEANUT SKINS ; FLAVONOIDS ; TANNINS
收录类别	SCI
资助信息	Korea Institute of Oriental Medicine [K12040, K13040]
语种	英语
WOS记录号	WOS:000326319700009
公开日期	2014-01-13
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/17425]
专题	昆明植物研究所_中国科学院东亚植物多样性与生物地理学重点实验室
作者单位	1.Korea Inst Oriental Med, Herbal Med Res Div, KM Based Herbal Drug Res Grp, Taejon 305811, South Korea 2.Gachon Univ, Dept Life Sci, Songnam 461701, Gyeonggi Do, South Korea 3.Chinese Acad Sci, Kunming Inst Bot, Lab Biodivers & Biogeog, Kunming 650204, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Lee, Ik-Soo,Yu, Song Yi,Jung, Seung-Hyun,et al. Proanthocyanidins from Spenceria ramalana and Their Effects on AGE Formation in Vitro and Hyaloid-Retinal Vessel Dilation in Larval Zebrafish in Vivo[J]. JOURNAL OF NATURAL PRODUCTS,2013,76(10):1881-1888.
APA	Lee, Ik-Soo.,Yu, Song Yi.,Jung, Seung-Hyun.,Lee, Yu-Ri.,Lee, Yun Mi.,...&Kim, Jin Sook.(2013).Proanthocyanidins from Spenceria ramalana and Their Effects on AGE Formation in Vitro and Hyaloid-Retinal Vessel Dilation in Larval Zebrafish in Vivo.JOURNAL OF NATURAL PRODUCTS,76(10),1881-1888.
MLA	Lee, Ik-Soo,et al."Proanthocyanidins from Spenceria ramalana and Their Effects on AGE Formation in Vitro and Hyaloid-Retinal Vessel Dilation in Larval Zebrafish in Vivo".JOURNAL OF NATURAL PRODUCTS 76.10(2013):1881-1888.