Molecular Interaction between a Gadolinium-Polyoxometalate and Human Serum Albumin

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	Molecular Interaction between a Gadolinium-Polyoxometalate and Human Serum Albumin
	Zheng, Li 2,3; Ma, Ying 2; Zhang, Guangjin 1; Yao, Jiannian 2; Bassil, Bassem S.4; Kortz, Ulrich 4; Keita, Bineta 5; de Oliveira, Pedro 5; Nadjo, Louis 5; Craescu, Constantin T.6
刊名	EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
	2009-12-01
卷号	34 期号:34 页码:5189-5193
关键词	Gadolinium Polyoxometalates Fluorescence Energy transfer Protein structures
ISSN号	1434-1948
通讯作者	Zhang, GJ
英文摘要	Polyoxometalates (POMs) show promising antibacterial, antiviral (particularly anti-HIV), antitumor, and anticancer activities, but the mechanism of these potential therapeutic effects remains to be elucidated at the molecular level. The interaction between the Gd-containing tungstosilicate [Gd(beta(2)-SiW(11)O(39))(2)](13-) and human serum albumin (HSA) was studied by several techniques. Fluorescence spectroscopy showed an energy transfer between the single tryptophan residue of HSA and the POM. Circular dichroism led to the conclusion that the POM significantly altered the secondary structure of HSA. Isothermal titration calorimetry revealed an enthalpy-driven binding reaction between HSA and the POM, resulting in the formation of a 1:1 complex. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Chemistry, Inorganic & Nuclear
研究领域[WOS]	Chemistry
关键词[WOS]	COMPLEXES
收录类别	SCI
语种	英语
WOS记录号	WOS:000272825000019
公开日期	2013-11-29
内容类型	期刊论文
版本	出版稿
源URL	[http://ir.ipe.ac.cn/handle/122111/6534]
专题	过程工程研究所_湿法冶金清洁生产技术国家工程实验室
作者单位	1.Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc Engn, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Key Lab Photochem, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 4.Jacobs Univ, Sch Sci & Engn, D-28725 Bremen, Germany 5.Univ Paris 11, CNRS, UMR 8000, Chim Phys Lab, F-91405 Orsay, France 6.Ctr Univ Paris Sud, INSERM, U759, Inst Curie Rech, F-91405 Orsay, France
推荐引用方式 GB/T 7714	Zheng, Li,Ma, Ying,Zhang, Guangjin,et al. Molecular Interaction between a Gadolinium-Polyoxometalate and Human Serum Albumin[J]. EUROPEAN JOURNAL OF INORGANIC CHEMISTRY,2009,34(34):5189-5193.
APA	Zheng, Li.,Ma, Ying.,Zhang, Guangjin.,Yao, Jiannian.,Bassil, Bassem S..,...&Miron, Simona.(2009).Molecular Interaction between a Gadolinium-Polyoxometalate and Human Serum Albumin.EUROPEAN JOURNAL OF INORGANIC CHEMISTRY,34(34),5189-5193.
MLA	Zheng, Li,et al."Molecular Interaction between a Gadolinium-Polyoxometalate and Human Serum Albumin".EUROPEAN JOURNAL OF INORGANIC CHEMISTRY 34.34(2009):5189-5193.