A New Cytotoxic Sesquiterpene Quinone Produced by Penicillium sp F00120 Isolated from a Deep Sea Sediment Sample

CORC > 南海海洋研究所 > 中国科学院南海海洋研究所 > 中科院海洋生物资源可持续利用重点实验室

	A New Cytotoxic Sesquiterpene Quinone Produced by Penicillium sp F00120 Isolated from a Deep Sea Sediment Sample
	Lin, XP ; Zhou, XF ; Wang, FZ ; Liu, KS ; Yang, B ; Yang, XW ; Peng, Y ; Liu, J ; Ren, Z ; Liu, YH
刊名	MARINE DRUGS
	2012
卷号	10 期号:1 页码:106-115
关键词	Penicillium sp F00120 sesquiterpene quinone cytotoxic deep sea sediment penicilliumin A
ISSN号	1660-3397
通讯作者	xiupinglin@hotmail.com ; xfzhou@scsio.ac.cn ; wangfazuo@scsio.ac.cn ; liukaisheng1987@163.com ; bingo525@163.com ; xwyang@scsio.ac.cn ; py00_2006@126.com ; ljuan2010@qq.com ; rz62@163.com ; yonghongliu@scsio.ac.cn
中文摘要	A new fungal strain, displaying strong toxic activity against brine shrimp larvae, was isolated from a deep sea sediment sample collected at a depth of 1300 m. The strain, designated as F00120, was identified as a member of the genus Penicillium on the basis of morphology and ITS sequence analysis. One new sesquiterpene quinone, named penicilliumin A (1), along with two known compounds ergosterol (2) and ergosterol peroxide (3), were isolated and purified from the cultures of F00120 by silica gel column, Sephadex LH-20 column, and preparative thin layer chromatography. Their structures were elucidated by detailed nuclear magnetic resonance (NMR) and mass spectroscopic (MS) analysis as well as comparison with literature data. The new compound penicilliumin A inhibited in vitro proliferation of mouse melanoma (B16), human melanoma (A375), and human cervical carcinoma (Hela) cell lines moderately.
学科主题	Chemistry, Medicinal
语种	英语
WOS记录号	WOS:000299541800007
公开日期	2013-08-28
内容类型	期刊论文
源URL	[http://ir.scsio.ac.cn/handle/344004/10022]
专题	南海海洋研究所_中科院海洋生物资源可持续利用重点实验室
推荐引用方式 GB/T 7714	Lin, XP,Zhou, XF,Wang, FZ,et al. A New Cytotoxic Sesquiterpene Quinone Produced by Penicillium sp F00120 Isolated from a Deep Sea Sediment Sample[J]. MARINE DRUGS,2012,10(1):106-115.
APA	Lin, XP.,Zhou, XF.,Wang, FZ.,Liu, KS.,Yang, B.,...&Liu, YH.(2012).A New Cytotoxic Sesquiterpene Quinone Produced by Penicillium sp F00120 Isolated from a Deep Sea Sediment Sample.MARINE DRUGS,10(1),106-115.
MLA	Lin, XP,et al."A New Cytotoxic Sesquiterpene Quinone Produced by Penicillium sp F00120 Isolated from a Deep Sea Sediment Sample".MARINE DRUGS 10.1(2012):106-115.