Novel porphyrin derivative containing cations as new photodynamic antimicrobial agent with high efficiency

doi:10.1039/d3ra07743h

CORC > 海洋研究所 > 中国科学院海洋研究所 > 海洋生态与环境科学重点实验室

	Novel porphyrin derivative containing cations as new photodynamic antimicrobial agent with high efficiency
	Zhang, Jiajing 2,3,4; Yuan, Xiaoqian 2; Li, Hongsen 2; Yu, Liting 2; Zhang, Yulong 2; Pang, Keyi 2; Sun, Chaoyue 2; Liu, Zhongyang 2; Li, Jie 2; Ma, Liying 2
刊名	RSC ADVANCES
	2024-01-17
卷号	14 期号:5 页码:3122-3134
DOI	10.1039/d3ra07743h
通讯作者	Ma, Liying() ; Chen, Lingxin(lxchen@yic.ac.cn)
英文摘要	Bacterial infections from chronic wounds affect about 175 million people each year and are a significant clinical problem. Through the integration of photodynamic therapy (PDT) and chemotherapy, a new photosensitizer consisting of ammonium salt N,N-bis-(2-hydroxyethyl)-N-(6-(4-(10,15,20-trimesitylporphyrin-5-yl) phenoxy) hexane)-N-methanaminium bromide, TMP(+) was successfully synthesized with a total reaction yield of 10%. The novel photosensitizer consists of two parts, a porphyrin photosensitizer part and a quaternary ammonium salt part, to achieve the synergistic effect of photodynamic and chemical antibacterial activity. With the increase of TMP(+) concentration, the diameter of the PCT fiber membranes (POL/COL/TMP(+); POL, polycaprolactone; COL, collagen) gradually increased, which was caused by the charge of the quaternary ammonium salt. At the same time, the antibacterial properties were gradually improved. We finally selected the PCT 0.5% group for the antibacterial experiment, with excellent performance in fiber uniformity, hydrophobicity and biosafety. The antibacterial experiment showed that the modified porphyrin TMP(+) had a better antibacterial effect than others. In vivo chronic wound healing experiments proved that the antibacterial and anti-inflammatory effect of the PCTL group was the best, further confirmed by H&E histological analysis, immunofluorescence and immunohistochemistry mechanism experiments. This research lays the foundation for the manufacture of novel molecules that combine chemical and photodynamic strategies. A new photosensitizer consisting of ammonium salt, TMP(+) was synthesized and achieved the synergistic effect of photodynamic and chemical antibacterial activity. Experiments showed promising bactericidal properties, while accelerating the healing of Staphylococcus aureus infected mice.
资助项目	National Natural Science Foundation of China[22001020] ; Foundation of Binzhou Medical University[2019KYQD23] ; Foundation of Binzhou Medical University[2022KYQD27]
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:001144849200001
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/184272]
专题	海洋研究所_海洋生态与环境科学重点实验室
通讯作者	Ma, Liying; Chen, Lingxin
作者单位	1.Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China 2.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China 3.Chinese Acad Sci, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Jiajing,Yuan, Xiaoqian,Li, Hongsen,et al. Novel porphyrin derivative containing cations as new photodynamic antimicrobial agent with high efficiency[J]. RSC ADVANCES,2024,14(5):3122-3134.
APA	Zhang, Jiajing.,Yuan, Xiaoqian.,Li, Hongsen.,Yu, Liting.,Zhang, Yulong.,...&Chen, Lingxin.(2024).Novel porphyrin derivative containing cations as new photodynamic antimicrobial agent with high efficiency.RSC ADVANCES,14(5),3122-3134.
MLA	Zhang, Jiajing,et al."Novel porphyrin derivative containing cations as new photodynamic antimicrobial agent with high efficiency".RSC ADVANCES 14.5(2024):3122-3134.