Natural products for infectious microbes and diseases: an overview of sources, compounds, and chemical diversities

doi:10.1007/s11427-020-1959-5

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	Natural products for infectious microbes and diseases: an overview of sources, compounds, and chemical diversities
	Luo, Lu ; Yang, Jun ; Wang, Cheng 5; Wu, Jie ; Li, Yafang 4; Zhang, Xu 3; Li, Hui 1; Zhang, Hui 2; Zhou, Yumei 6; Lu, Aiping 8
刊名	SCIENCE CHINA-LIFE SCIENCES
	2022
卷号	65 期号:6 页码:1123-1145
关键词	natural product infectious pathogen drug discovery drug development in silico analysis
ISSN号	1674-7305
DOI	10.1007/s11427-020-1959-5
文献子类	Review
英文摘要	As coronavirus disease 2019 (COVID-19) threatens human health globally, infectious disorders have become one of the most challenging problem for the medical community. Natural products (NP) have been a prolific source of antimicrobial agents with widely divergent structures and a range vast biological activities. A dataset comprising 618 articles, including 646 NP-based compounds from 672 species of natural sources with biological activities against 21 infectious pathogens from five categories, was assembled through manual selection of published articles. These data were used to identify 268 NP-based compounds classified into ten groups, which were used for network pharmacology analysis to capture the most promising lead-compounds such as agelasine D, dicumarol, dihydroartemisinin and pyridomycin. The distribution of maximum Tanimoto scores indicated that compounds which inhibited parasites exhibited low diversity, whereas the chemistries inhibiting bacteria, fungi, and viruses showed more structural diversity. A total of 331 species of medicinal plants with compounds exhibiting antimicrobial activities were selected to classify the family sources. The family Asteraceae possesses various compounds against C. neoformans, the family Anacardiaceae has compounds against Salmonella typhi, the family Cucurbitacea against the human immunodeficiency virus (HIV), and the family Ancistrocladaceae against Plasmodium. This review summarizes currently available data on NP-based antimicrobials against refractory infections to provide information for further discovery of drugs and synthetic strategies for anti-infectious agents.
学科主题	Biology
电子版国际标准刊号	1869-1889
出版地	BEIJING
WOS关键词	TRADITIONAL CHINESE MEDICINE ; DRUG DISCOVERY ; IN-VITRO ; CRYPTOCOCCAL MENINGITIS ; ANTIVIRAL ACTIVITY ; DATABASE ; PRION ; INHIBITION ; ANTIFUNGAL ; DESIGN
WOS研究方向	Science Citation Index Expanded (SCI-EXPANDED)
语种	英语
出版者	SCIENCE PRESS
WOS记录号	WOS:000712497300002
资助机构	Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences [CI2021A04013] ; Fundamental Research Funds for the Central Public Welfare Research Institutes [L2021029]
内容类型	期刊论文
源URL	[http://ir.ibcas.ac.cn/handle/2S10CLM1/28476]
专题	中科院北方资源植物重点实验室
作者单位	1.weMED Hlth, Houston, TX 77054 USA 2.Chinese Acad Sci, Inst Bot, Beijing 100093, Peoples R China 3.Chinese Acad Med Sci & Peking Union Med Coll, Inst Hematol & Blood Dis Hosp, Tianjin 300020, Peoples R China 4.Chinese Acad Med Sci & Peking Union Med Coll, Inst Basic Med Sci, Beijing 100006, Peoples R China 5.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China 6.Akupunktur Akademiet, DK-8230 Aabyhoej, Denmark 7.Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong 999077, Peoples R China 8.Guangzhou Univ Chinese Med, Clin Med Coll 4, Guangzhou 518033, Peoples R China
推荐引用方式 GB/T 7714	Luo, Lu,Yang, Jun,Wang, Cheng,et al. Natural products for infectious microbes and diseases: an overview of sources, compounds, and chemical diversities[J]. SCIENCE CHINA-LIFE SCIENCES,2022,65(6):1123-1145.
APA	Luo, Lu.,Yang, Jun.,Wang, Cheng.,Wu, Jie.,Li, Yafang.,...&Chen, Shilin.(2022).Natural products for infectious microbes and diseases: an overview of sources, compounds, and chemical diversities.SCIENCE CHINA-LIFE SCIENCES,65(6),1123-1145.
MLA	Luo, Lu,et al."Natural products for infectious microbes and diseases: an overview of sources, compounds, and chemical diversities".SCIENCE CHINA-LIFE SCIENCES 65.6(2022):1123-1145.