Connected function of PRAF/RLD and GNOM in membrane trafficking controls intrinsic cell polarity in plants

doi:10.1038/s41467-021-27748-w

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	Connected function of PRAF/RLD and GNOM in membrane trafficking controls intrinsic cell polarity in plants
	Wang, Lu 7; Li, Dongmeng 7; Yang, Kezhen 8; Guo, Xiaoyu ; Bian, Chao 4,5,7; Nishimura, Takeshi 9; Le, Jie 1,8; Morita, Miyo Terao 9; Bergmann, Dominique C.; Dong, Juan 7
刊名	NATURE COMMUNICATIONS
	2022
卷号	13 期号:1
DOI	10.1038/s41467-021-27748-w
文献子类	Article
英文摘要	Cell polarity is a fundamental feature underlying cell morphogenesis and organismal development. In the Arabidopsis stomatal lineage, the polarity protein BASL controls stomatal asymmetric cell division. However, the cellular machinery by which this intrinsic polarity site is established remains unknown. Here, we identify the PRAF/RLD proteins as BASL physical partners and mutating four PRAF members leads to defects in BASL polarization. Members of PRAF proteins are polarized in stomatal lineage cells in a BASL-dependent manner. Developmental defects of the praf mutants phenocopy those of the gnom mutants. GNOM is an activator of the conserved Arf GTPases and plays important roles in membrane trafficking. We further find PRAF physically interacts with GNOM in vitro and in vivo. Thus, we propose that the positive feedback of BASL and PRAF at the plasma membrane and the connected function of PRAF and GNOM in endosomal trafficking establish intrinsic cell polarity in the Arabidopsis stomatal lineage.
学科主题	Multidisciplinary Sciences
电子版国际标准刊号	2041-1723
出版地	BERLIN
WOS关键词	TRANS-GOLGI NETWORK ; PLASMA-MEMBRANE ; SUBCELLULAR-LOCALIZATION ; AUXIN TRANSPORT ; ARF-GEF ; DIVISION ; RAB ; GENE ; PHOSPHORYLATION ; MECHANISMS
WOS研究方向	Science Citation Index Expanded (SCI-EXPANDED)
语种	英语
出版者	NATURE PORTFOLIO
WOS记录号	WOS:001028235600001
资助机构	National Institute of Health [GM109080, GM131827] ; National Science Foundation [1851907, 1952823] ; National Natural Science Foundation of China [31771515, 31970804, 31871377] ; Core Research for Evolutional Science and Technology (CREST) award from the Japan Science and Technology Agency (JST) [JPMJCR14M5]
内容类型	期刊论文
源URL	[http://ir.ibcas.ac.cn/handle/2S10CLM1/28745]
专题	中科院植物分子生理学重点实验室
作者单位	1.Natl Inst Basic Biol, Div Plant Environm Responses, Okazaki 4448556, Japan 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Bergmann, Dominique C.] Stanford Univ, Dept Biol, Stanford, CA 94305 USA 4.Bergmann, Dominique C.] Howard Hughes Med Inst, Stanford, CA 94305 USA 5.Univ Calif Davis, Dept Plant Biol, Davis, CA 95616 USA 6.Univ Calif Davis, Genome Ctr, Davis, CA 95616 USA 7.Rutgers State Univ, Waksman Inst Microbiol, Piscataway, NJ 08854 USA 8.Rutgers State Univ, Dept Plant Biol, New Brunswick, NJ 08901 USA 9.Chinese Acad Sci, Inst Bot, CAS Ctr Excellence Mol Plant Sci, Key Lab Plant Mol Physiol, Beijing 100093, Peoples R China
推荐引用方式 GB/T 7714	Wang, Lu,Li, Dongmeng,Yang, Kezhen,et al. Connected function of PRAF/RLD and GNOM in membrane trafficking controls intrinsic cell polarity in plants[J]. NATURE COMMUNICATIONS,2022,13(1).
APA	Wang, Lu.,Li, Dongmeng.,Yang, Kezhen.,Guo, Xiaoyu.,Bian, Chao.,...&Dong, Juan.(2022).Connected function of PRAF/RLD and GNOM in membrane trafficking controls intrinsic cell polarity in plants.NATURE COMMUNICATIONS,13(1).
MLA	Wang, Lu,et al."Connected function of PRAF/RLD and GNOM in membrane trafficking controls intrinsic cell polarity in plants".NATURE COMMUNICATIONS 13.1(2022).