DNA intercalation makes possible superior-gain organic photoelectrochemical transistor detection

doi:10.1016/j.bios.2023.115543

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	DNA intercalation makes possible superior-gain organic photoelectrochemical transistor detection
	Zhu, Yu-Yue 2,5,7; Jiang, Tian-Tong 2; Gao, Ge 4,7; Wang, Shi-Liang 2,3; Jiang, Xing-Wu 2,6,7; Xu, Yi-Tong 7; Zhai, Xiao-Fan 1; Zhou, Hong 4; Zhao, Wei-Wei 7
刊名	BIOSENSORS & BIOELECTRONICS
	2023-10-01
卷号	237 页码:6
关键词	Organic photoelectrochemical electronics Bioanalysis DNA intercalation Superior gain
ISSN号	0956-5663
DOI	10.1016/j.bios.2023.115543
通讯作者	Zhai, Xiao-Fan(zhaixf@qdio.ac.cn) ; Zhou, Hong(zhouhong@qust.edu.cn) ; Zhao, Wei-Wei(zww@nju.edu.cn)
英文摘要	DNA intercalation has increasingly been studied for various scenario implementations due to the diverse func-tions of DNA/intercalators. Nascent organic photoelectrochemical transistor (OPECT) biosensing taking place in organic electronics and photoelectrochemical bioanalysis represents a promising technological frontier in the arena. In this work, we first devise DNA intercalation-enabled OPECT for miRNA detection with a superior gain up to 17100. Intercalation of [Ru(bpy)2dppz]2+ within the miRNA-initiated hybrid chain reaction (HCR)-derived duplex DNA is realized for producing anodic photocurrent upon light stimulation, causing the corresponding target-dependent alternation in gate voltage (VG) and hence the modulated channel current (IDS) of poly (3,4-ethylenedioxythiophene) doped with poly (styrene sulfonate) (PEDOT:PSS) under specific drain voltage (VDS) for quantitative miRNA-21 analysis, which shows a wide linear relationship and a low detection limit of 5.5 x 10-15 mol L-1. This study features the DNA intercalation-enabled organic electronics with superior gain and is envisaged to attract more attention to explore DNA adducts for innovative bioelectronics and biosensing, given the diverse DNA binders with multiple functions.
资助项目	National Natural Science Foundation of China[22174063] ; Basic Scientific Fund for National Public Research Institutes of China[2019Y03] ; Basic Scientific Fund for National Public Research Institutes of China[2020S02] ; Open Fund of Shandong Key Laboratory of Marine Ecological Environment and Disaster Prevention and Mitigation[202203] ; Open Fund of Guangxi Key Laboratory of Beibu Gulf Marine Resources, Environment and Sus-tainable Development[MRESD-2022-A03] ; Open Fund of Guangxi Key Laboratory of Beibu Gulf Marine Resources, Environment and Sustainable Development[MRESD-2022-A03] ; Young Elite Scientists Sponsorship Program by CAST[YESS20210201]
WOS关键词	COMPLEX ; SENSOR
WOS研究方向	Biophysics ; Biotechnology & Applied Microbiology ; Chemistry ; Electrochemistry ; Science & Technology - Other Topics
语种	英语
出版者	ELSEVIER ADVANCED TECHNOLOGY
WOS记录号	WOS:001047366300001
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/182747]
专题	海洋研究所_海洋腐蚀与防护研究发展中心
通讯作者	Zhai, Xiao-Fan; Zhou, Hong; Zhao, Wei-Wei
作者单位	1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Environm Corros & Biofouling, 7 Nanhai Rd, Qingdao 266071, Peoples R China 2.Minist Nat Resources, Inst Oceanog 1, Marine Bioresource & Environm Res Ctr, Key Lab Marine Ecoenvironm Sci & Technol, 6 Xianxialing Rd, Qingdao 266061, Peoples R China 3.Shandong Univ Sci & Technol, Coll Safety & Environm Engn, Qingdao 266590, Peoples R China 4.Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Shandong Key Lab Biochem Anal, Qingdao 266042, Peoples R China 5.Guangxi Univ, Coll Chem & Chem Engn, Nanning 530004, Peoples R China 6.Shandong Key Lab Marine Ecol Environm & Disaster P, Qingdao 266061, Peoples R China 7.Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Analyt Chem Life Sci, Nanjing 210023, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Yu-Yue,Jiang, Tian-Tong,Gao, Ge,et al. DNA intercalation makes possible superior-gain organic photoelectrochemical transistor detection[J]. BIOSENSORS & BIOELECTRONICS,2023,237:6.
APA	Zhu, Yu-Yue.,Jiang, Tian-Tong.,Gao, Ge.,Wang, Shi-Liang.,Jiang, Xing-Wu.,...&Zhao, Wei-Wei.(2023).DNA intercalation makes possible superior-gain organic photoelectrochemical transistor detection.BIOSENSORS & BIOELECTRONICS,237,6.
MLA	Zhu, Yu-Yue,et al."DNA intercalation makes possible superior-gain organic photoelectrochemical transistor detection".BIOSENSORS & BIOELECTRONICS 237(2023):6.