Rubensteroid A, a new steroid with antibacterial activity from Penicillium rubens AS-130

doi:10.1038/s41429-023-00634-x

CORC > 海洋研究所 > 中国科学院海洋研究所 > 实验海洋生物学重点实验室

	Rubensteroid A, a new steroid with antibacterial activity from Penicillium rubens AS-130
	Ying, Zhen 2,3; Li, Xiao-Ming 3; Wang, Bin-Gui 1,2,3; Li, Hong-Lei 3; Meng, Ling-Hong 2,3
刊名	JOURNAL OF ANTIBIOTICS
	2023-05-31
页码	4
ISSN号	0021-8820
DOI	10.1038/s41429-023-00634-x
通讯作者	Li, Hong-Lei(lihonglei@qdio.ac.cn) ; Meng, Ling-Hong(menglh@ms.qdio.ac.cn)
英文摘要	A new steroid with strong antibacterial activity, rubensteroid A (1), along with its decarboxylic analogue, solitumergosterol A (2), were isolated and identified from the Magellan Seamount-derived fungus Penicillium rubens AS-130. The structure and absolute configuration of compound 1 were established by detailed interpretation of NMR spectroscopic analysis, mass spectrometry data, and TDDFT-ECD calculations. Compound 1 had a rare 6/6/6/6/5 pentacyclic system, which might be the [4 + 2] Diels-Alder adduct of 14,15-didehydroergosterol (14-DHE) cycloaddition with maleic acid or maleimide, followed by decarboxylation. Rubensteroid A (1) exhibited potent antibacterial activity against Escherichia coli and Vibrio parahaemolyticus, both with MIC value of 0.5 mu g/mL.
资助项目	National Natural Science Foundation of China[U2006203] ; National Natural Science Foundation of China[41976090] ; National Natural Science Foundation of China[42176115] ; Natural Science Foundation of Shandong Province[ZR2018BD031] ; China Postdoctoral Science Foundation[2018M632732]
WOS研究方向	Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy
语种	英语
出版者	SPRINGERNATURE
WOS记录号	WOS:000998234400001
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/183216]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Li, Hong-Lei; Meng, Ling-Hong
作者单位	1.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China 2.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Ying, Zhen,Li, Xiao-Ming,Wang, Bin-Gui,et al. Rubensteroid A, a new steroid with antibacterial activity from Penicillium rubens AS-130[J]. JOURNAL OF ANTIBIOTICS,2023:4.
APA	Ying, Zhen,Li, Xiao-Ming,Wang, Bin-Gui,Li, Hong-Lei,&Meng, Ling-Hong.(2023).Rubensteroid A, a new steroid with antibacterial activity from Penicillium rubens AS-130.JOURNAL OF ANTIBIOTICS,4.
MLA	Ying, Zhen,et al."Rubensteroid A, a new steroid with antibacterial activity from Penicillium rubens AS-130".JOURNAL OF ANTIBIOTICS (2023):4.