New ophiobolin sesterterpenoid and drimane sesquiterpenoids from a marine-alga-derived fungus<i> Aspergillus</i> sp.

doi:10.1016/j.fitote.2023.105659

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 海岸带生物学与生物资源利用重点实验室

	New ophiobolin sesterterpenoid and drimane sesquiterpenoids from a marine-alga-derived fungus Aspergillus sp.
	Fang, Sheng-Tao; Shi, Zhen-Zhen; Song, Yin-Ping; Yin, Xiu-Li; Ji, Nai-Yun
刊名	FITOTERAPIA
	2023-10-01
卷号	170 页码:6
关键词	Marine fungus Aspergillus Ophiobolin sesterterpenoid Drimane sesquiterpenoid Anti-microalgal activity
ISSN号	0367-326X
DOI	10.1016/j.fitote.2023.105659
通讯作者	Ji, Nai-Yun(nyji@yic.ac.cn)
英文摘要	Further investigation of secondary metabolites of a marine-alga-derived fungus Aspergillus sp. RR-YLW-12 led to isolate one new ophiobolin-type sesterterpenoid (1), four new drimane-type sesquiterpenoids (2-5) and one natural occurring compound (6), together with seven known compounds (7-13). Their structures and stereo chemistry were elucidated by extensive spectroscopic analysis of NMR and HRMS experiments, and by comparison with the literature data. All isolates were evaluated for growth inhibition of five marine harmful microalgae. The new compounds exhibited significant to moderate inhibitory effects towards all tested micro algae species with IC50 values ranging from 5.8 to 54.5 & mu;g/mL.
WOS研究方向	Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:001072059600001
资助机构	Promotion Association of the CAS ; Taishan Scholar Project Special Funding
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/32857]
专题	海岸带生物学与生物资源利用重点实验室
通讯作者	Ji, Nai-Yun
作者单位	Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Fang, Sheng-Tao,Shi, Zhen-Zhen,Song, Yin-Ping,et al. New ophiobolin sesterterpenoid and drimane sesquiterpenoids from a marine-alga-derived fungus Aspergillus sp.[J]. FITOTERAPIA,2023,170:6.
APA	Fang, Sheng-Tao,Shi, Zhen-Zhen,Song, Yin-Ping,Yin, Xiu-Li,&Ji, Nai-Yun.(2023).New ophiobolin sesterterpenoid and drimane sesquiterpenoids from a marine-alga-derived fungus Aspergillus sp..FITOTERAPIA,170,6.
MLA	Fang, Sheng-Tao,et al."New ophiobolin sesterterpenoid and drimane sesquiterpenoids from a marine-alga-derived fungus Aspergillus sp.".FITOTERAPIA 170(2023):6.