A crosswalk on the genetic and conventional strategies for enhancing astaxanthin production in <i>Haematococcus pluvialis</i>

doi:10.1080/07388551.2023.2240009

	A crosswalk on the genetic and conventional strategies for enhancing astaxanthin production in Haematococcus pluvialis
	Acheampong, Adolf 1,2; Li, Lamei 1,2; Elsherbiny, Shereen M.1,2; Wu, Yahui 1,2; Swallah, Mohammed Sharif 1,2; Bondzie-Quaye, Precious 1,2; Huang, Qing 1,2
刊名	CRITICAL REVIEWS IN BIOTECHNOLOGY
	2023-09-30
关键词	Haematococcus pluvialis astaxanthin genetic engineering mutagenesis transcriptome analysis phytohormones
ISSN号	0738-8551
DOI	10.1080/07388551.2023.2240009
通讯作者	Huang, Qing(huangq@ipp.ac.cn)
英文摘要	Astaxanthin is a naturally occurring xanthophyll with powerful: antioxidant, antitumor, and antibacterial properties that are widely employed in food, feed, medicinal and nutraceutical industries. Currently, chemical synthesis dominates the world's astaxanthin market, but the increasing demand for natural products is shifting the market for natural astaxanthin. Haematococcus pluvialis (H. pluvialis) is the factory source of natural astaxanthin when grown in optimal conditions. Currently, various strategies for the production of astaxanthin have been proposed or are being developed in order to meet its market demand. This up-to-date review scrutinized the current approaches or strategies that aim to increase astaxanthin yield from H. pluvialis. We have emphasized the genetic and environmental parameters that increase astaxanthin yield. We also looked at the transcriptomic dynamics caused by environmental factors (phytohormones induction, light, salt, temperature, and nutrient starvation) on astaxanthin synthesizing genes and other metabolic changes. Genetic engineering and culture optimization (environmental factors) are effective approaches to producing more astaxanthin for commercial purposes. Genetic engineering, in particular, is accurate, specific, potent, and safer than conventional random mutagenesis approaches. New technologies, such as CRISPR-Cas9 coupled with omics and emerging computational tools, may be the principal strategies in the future to attain strains that can produce more astaxanthin. This review provides accessible data on the strategies to increase astaxanthin accumulation natively. Also, this review can be a starting point for new scholars interested in H. pluvialis research.
资助项目	ANSO Scholarship board
WOS关键词	BETA-CAROTENE KETOLASE ; LIPID PRODUCTION ; 1-AMINOCYCLOPROPANE-1-CARBOXYLIC ACID ; HYPERPRODUCING MUTANTS ; ABSCISIC-ACID ; HIGH LIGHT ; ACCUMULATION ; STRESS ; CULTIVATION ; MICROALGAE
WOS研究方向	Biotechnology & Applied Microbiology
语种	英语
出版者	TAYLOR & FRANCIS LTD
WOS记录号	WOS:001076789400001
资助机构	ANSO Scholarship board
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/132643]
专题	中国科学院合肥物质科学研究院
通讯作者	Huang, Qing
作者单位	1.Univ Sci & Technol China, Sci Isl Branch, Grad Sch, Hefei, Peoples R China 2.Chinese Acad Sci, CAS Key Lab High Magnet Field & Iron Beam Phys Bio, Inst Intelligent Machines, Hefei Inst Phys Sci, Hefei, Peoples R China
推荐引用方式 GB/T 7714	Acheampong, Adolf,Li, Lamei,Elsherbiny, Shereen M.,et al. A crosswalk on the genetic and conventional strategies for enhancing astaxanthin production in Haematococcus pluvialis[J]. CRITICAL REVIEWS IN BIOTECHNOLOGY,2023.
APA	Acheampong, Adolf.,Li, Lamei.,Elsherbiny, Shereen M..,Wu, Yahui.,Swallah, Mohammed Sharif.,...&Huang, Qing.(2023).A crosswalk on the genetic and conventional strategies for enhancing astaxanthin production in Haematococcus pluvialis.CRITICAL REVIEWS IN BIOTECHNOLOGY.
MLA	Acheampong, Adolf,et al."A crosswalk on the genetic and conventional strategies for enhancing astaxanthin production in Haematococcus pluvialis".CRITICAL REVIEWS IN BIOTECHNOLOGY (2023).