Biomechanics in liver regeneration after partial hepatectomy

doi:10.3389/fbioe.2023.1165651

	Biomechanics in liver regeneration after partial hepatectomy
	Wu Y(武亿); Li N(李宁); Shu XY(舒芯钰); Li W(李旺); Zhang XY(张晓宇); Lv DY(吕东媛); Long M(龙勉)
刊名	FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
	2023-05-05
卷号	11 页码:1165651
关键词	liver regeneration partial hepatectomy hemodynamics mechanical loading mechanotransduction
ISSN号	2296-4185
DOI	10.3389/fbioe.2023.1165651
英文摘要	The liver is a complicated organ within the body that performs wide-ranging and vital functions and also has a unique regenerative capacity after hepatic tissue injury and cell loss. Liver regeneration from acute injury is always beneficial and has been extensively studied. Experimental models including partial hepatectomy (PHx) reveal that extracellular and intracellular signaling pathways can help the liver recover to its equivalent size and weight prior to an injury. In this process, mechanical cues possess immediate and drastic changes in liver regeneration after PHx and also serve as main triggering factors and significant driving forces. This review summarized the biomechanics progress in liver regeneration after PHx, mainly focusing on PHx-based hemodynamics changes in liver regeneration and the decoupling of mechanical forces in hepatic sinusoids including shear stress, mechanical stretch, blood pressure, and tissue stiffness. Also discussed were the potential mechanosensors, mechanotransductive pathways, and mechanocrine responses under varied mechanical loading in vitro. Further elucidating these mechanical concepts in liver regeneration helps establish a comprehensive understanding of the biochemical factors and mechanical cues in this process. Proper adjustment of mechanical loading within the liver might preserve and restore liver functions in clinical settings, serving as an effective therapy for liver injury and diseases.
分类号	二类/Q1
WOS研究方向	Biotechnology & Applied Microbiology ; Multidisciplinary Sciences
语种	英语
WOS记录号	WOS:000999296300001
资助机构	National Key Research and Development Program of China [2021YFA0719302] ; National Natural Science Foundation of China [32130061, 31870931]
其他责任者	Lu, DY ; Long, M (corresponding author), Chinese Acad Sci, Ctr Biomech & Bioengn, Beijing Key Lab Engn Construct & Mechanobiol, Beijing, Peoples R China. ; Lu, DY ; Long, M (corresponding author), Chinese Acad Sci, Inst Mech, Key Lab Micrograv, Nat Micrograv Lab, Beijing, Peoples R China. ; Lu, DY ; Long, M (corresponding author), Univ Chinese Acad Sci, Sch Engn Sci, Beijing, Peoples R China.
内容类型	期刊论文
源URL	[http://dspace.imech.ac.cn/handle/311007/92437]
专题	力学研究所_国家微重力实验室
作者单位	1.{Wu Yi, Li Ning, Shu Xinyu, Li Wang, Zhang Xiaoyu, Lu Dongyuan, Long Mian} Univ Chinese Acad Sci Sch Engn Sci Beijing Peoples R China 2.{Wu Yi, Li Ning, Shu Xinyu, Li Wang, Zhang Xiaoyu, Lu Dongyuan, Long Mian} Chinese Acad Sci Inst Mech Key Lab Micrograv Nat Micrograv Lab Beijing Peoples R China 3.{Wu Yi, Li Ning, Shu Xinyu, Li Wang, Zhang Xiaoyu, Lu Dongyuan, Long Mian} Chinese Acad Sci Ctr Biomech & Bioengn Beijing Key Lab Engn Construct & Mechanobiol Beijing Peoples R China
推荐引用方式 GB/T 7714	Wu Y,Li N,Shu XY,et al. Biomechanics in liver regeneration after partial hepatectomy[J]. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY,2023,11:1165651.
APA	武亿.,李宁.,舒芯钰.,李旺.,张晓宇.,...&龙勉.(2023).Biomechanics in liver regeneration after partial hepatectomy.FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY,11,1165651.
MLA	武亿,et al."Biomechanics in liver regeneration after partial hepatectomy".FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 11(2023):1165651.