Cellular proteins act as surfactants to control the interfacial behavior and function of biological condensates

doi:10.1016/j.devcel.2023.04.004

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	Cellular proteins act as surfactants to control the interfacial behavior and function of biological condensates
	Wang, Zheng ; Yang, Chun ; Guan DS(关东石); Li, Jiaqi ; Zhang, Hong
刊名	DEVELOPMENTAL CELL ; 11
	2023-06-05
卷号	58 页码:919
ISSN号	1534-5807
DOI	10.1016/j.devcel.2023.04.004
英文摘要	Interfacial tension governs the behaviors and physiological functions of multiple biological condensates dur-ing diverse biological processes. Little is known about whether there are cellular surfactant factors that regu-late the interfacial tension and functions of biological condensates within physiological environments. TFEB, a master transcription factor that controls expression of autophagic-lysosomal genes, assembles into tran-scriptional condensates to control the autophagy-lysosome pathway (ALP). Here, we show that interfacial tension modulates the transcriptional activity of TFEB condensates. MLX, MYC, and IPMK act as synergistic surfactants to decrease the interfacial tension and consequent DNA affinity of TFEB condensates. The inter-facial tension of TFEB condensates is quantitatively correlated to their DNA affinity and subsequent ALP ac-tivity. The interfacial tension and DNA affinity of condensates formed by TAZ-TEAD4 are also regulated by the synergistic surfactant proteins RUNX3 and HOXA4. Our results indicate that the interfacial tension and functions of biological condensates can be controlled by cellular surfactant proteins in human cells.
分类号	一类
WOS研究方向	Cell Biology ; Developmental Biology
语种	英语
WOS记录号	WOS:001011548600001
资助机构	National Natural Science Foundation of China [82188101, 31871426]
其他责任者	Wang, Z (corresponding author), Inst Biophys, Chinese Acad Sci, CAS Ctr Excellence Biomacromolecules, Natl Lab Biomacromolecules, Beijing 100101, Peoples R China.
内容类型	期刊论文
源URL	[http://dspace.imech.ac.cn/handle/311007/92431]
专题	力学研究所_非线性力学国家重点实验室
作者单位	1.{Guan Dongshi} Chinese Acad Sci Inst Mech State Key Lab Nonlinear Mech Beijing 100190 Peoples R China 2.{Yang Chun, Li Jiaqi, Zhang Hong} Univ Chinese Acad Sci Coll Life Sci Beijing 100049 Peoples R China 3.{Wang Zheng, Yang Chun, Zhang Hong} Inst Biophys Chinese Acad Sci CAS Ctr Excellence Biomacromolecules Natl Lab Biomacromolecules Beijing 100101 Peoples R China
推荐引用方式 GB/T 7714	Wang, Zheng,Yang, Chun,Guan DS,et al. Cellular proteins act as surfactants to control the interfacial behavior and function of biological condensates[J]. DEVELOPMENTAL CELL, 11,2023,58:919.
APA	Wang, Zheng,Yang, Chun,关东石,Li, Jiaqi,&Zhang, Hong.(2023).Cellular proteins act as surfactants to control the interfacial behavior and function of biological condensates.DEVELOPMENTAL CELL,58,919.
MLA	Wang, Zheng,et al."Cellular proteins act as surfactants to control the interfacial behavior and function of biological condensates".DEVELOPMENTAL CELL 58(2023):919.