Visible Particle Identification Using Raman Spectroscopy and Machine Learning

doi:10.1208/s12249-022-02335-4

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	Visible Particle Identification Using Raman Spectroscopy and Machine Learning
	H. Sheng; Y. P. Zhao; X. A. Long; L. W. Chen; B. Li; Y. Y. Fei; L. Mi and J. Ma
刊名	Aaps Pharmscitech
	2022
卷号	23 期号:6 页码:12
ISSN号	1530-9932
DOI	10.1208/s12249-022-02335-4
英文摘要	Visible particle identification is a crucial prerequisite step for process improvement and control during the manufacturing of injectable biotherapeutic drug products. Raman spectroscopy is a technology with several advantages for particle identification including high chemical sensitivity, minimal sample manipulation, and applicability to aqueous solutions. However, considerable effort and experience are required to extract and interpret Raman spectral data. In this study, we applied machine learning algorithms to analyze Raman spectral data for visible particle identification in order to minimize expert support and improve data analysis accuracy. We manually prepared ten types of particle standard solutions to simulate the particle types typically observed during manufacturing and established a Raman spectral library with accurate peak assignments for the visible particles. Five classification algorithms were trained using visible particle Raman spectral data. All models had high prediction accuracy of >98% for all types of visible particles. Our results demonstrate that the combination of Raman spectroscopy and machine learning can provide a simple and accurate data analysis approach for visible particle identification.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.ciomp.ac.cn/handle/181722/67232]
专题	中国科学院长春光学精密机械与物理研究所
推荐引用方式 GB/T 7714	H. Sheng,Y. P. Zhao,X. A. Long,et al. Visible Particle Identification Using Raman Spectroscopy and Machine Learning[J]. Aaps Pharmscitech,2022,23(6):12.
APA	H. Sheng.,Y. P. Zhao.,X. A. Long.,L. W. Chen.,B. Li.,...&L. Mi and J. Ma.(2022).Visible Particle Identification Using Raman Spectroscopy and Machine Learning.Aaps Pharmscitech,23(6),12.
MLA	H. Sheng,et al."Visible Particle Identification Using Raman Spectroscopy and Machine Learning".Aaps Pharmscitech 23.6(2022):12.