A Review of Histocytological Events and Molecular Mechanisms Involved in Intestine Regeneration in Holothurians

doi:10.3390/biology11081095

CORC > 海洋研究所 > 中国科学院海洋研究所 > 海洋生态与环境科学重点实验室

	A Review of Histocytological Events and Molecular Mechanisms Involved in Intestine Regeneration in Holothurians
	Su, Fang 2,3,4,5,6,7; Yang, Hongsheng 1,2,3,4,5,6,7; Sun, Lina 2,3,4,5,6,7
刊名	BIOLOGY-BASEL
	2022-08-01
卷号	11 期号:8 页码:15
关键词	sea cucumber evisceration regeneration holothurian echinoderm
DOI	10.3390/biology11081095
通讯作者	Sun, Lina(sunlina@qdio.ac.cn)
英文摘要	Simple Summary Many species of sea cucumber in Echinodermata may eviscerate most of or even all internal organs when encountering predators or adverse environments, and can achieve regeneration within a certain time. Although regeneration time varies, the mechanism is common. This paper reviewed the intestinal regeneration process of sea cucumbers from the perspectives of histocytology and molecular mechanism. Echinodermata has a special evolutionary position between achordate and chordate, so we hope to explore the common regeneration conserved signals between invertebrates and vertebrates by recording the intestinal regeneration of sea cucumbers. Most species of the class Holothuroidea are able to regenerate most of their internal organs following a typical evisceration process, which is a unique mechanism that allows sea cucumbers to survive in adverse environments. In this review, we compare autotomy among different type of sea cucumber and summarize the histocytological events that occur during the five stages of intestinal regeneration. Multiple cytological activities, such as apoptosis and dedifferentiation, take place during wound healing and anlage formation. Many studies have focused on the molecular regulation mechanisms that underlie regeneration, and herein we describe the techniques that have been used as well as the development-related signaling pathways and key genes that are significantly expressed during intestinal regeneration. Future analyses of the underlying mechanisms responsible for intestinal regeneration should include mapping at the single-cell level. Studies of visceral regeneration in echinoderms provide a unique perspective for understanding whole-body regeneration or appendage regeneration.
资助项目	National Natural Science Foundation of China[42076093]
WOS研究方向	Life Sciences & Biomedicine - Other Topics
语种	英语
出版者	MDPI
WOS记录号	WOS:000846947600001
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/180909]
专题	海洋研究所_海洋生态与环境科学重点实验室
通讯作者	Sun, Lina
作者单位	1.Chinese Acad Sci, Innovat Seed Design, Wuhan 430071, Peoples R China 2.Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, CAS Engn Lab Marine Ranching, Qingdao 266071, Peoples R China 5.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China 6.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao 266237, Peoples R China 7.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Su, Fang,Yang, Hongsheng,Sun, Lina. A Review of Histocytological Events and Molecular Mechanisms Involved in Intestine Regeneration in Holothurians[J]. BIOLOGY-BASEL,2022,11(8):15.
APA	Su, Fang,Yang, Hongsheng,&Sun, Lina.(2022).A Review of Histocytological Events and Molecular Mechanisms Involved in Intestine Regeneration in Holothurians.BIOLOGY-BASEL,11(8),15.
MLA	Su, Fang,et al."A Review of Histocytological Events and Molecular Mechanisms Involved in Intestine Regeneration in Holothurians".BIOLOGY-BASEL 11.8(2022):15.