Osmotic release of drugs via deswelling dynamics of microgels: modeling of collaborative flow and diffusions

doi:10.1039/d2cp02668f

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	Osmotic release of drugs via deswelling dynamics of microgels: modeling of collaborative flow and diffusions
	Sui JZ(隋济泽)
刊名	PHYSICAL CHEMISTRY CHEMICAL PHYSICS
	2022-11-23
页码	9
ISSN号	1463-9076
DOI	10.1039/d2cp02668f
通讯作者	Sui, Jize(suijize2008@126.com)
英文摘要	Hydrogel colloids, i.e., micro- or nano-gels, are increasingly engineered as promising vehicles for polymer-based drug delivery systems. We report a continuum theory of deswelling dynamics of nanocomposite microgels driven by external osmotic shocks and further develop a universal framework, by introducing a buffer release domain, to quantitatively characterize a continuous drug release from deswollen microgels towards surroundings. The drug release is shown to proceed accompanied by an active outward solvent flow created by the elastically shrunken gel network. We further find that a declining trend in the cumulative release plateau with the drug size is followed by an apparent increase again as the drug size increases above a threshold. These findings highlight a nontrivial behavior that the resulting hydrodynamic interactions coexist collaboratively with the passive diffusions to facilitate a desired drug release. We show that deswelling of a stiffer microgel (the mesh size reduces slowly) or loading the larger drugs could bring a control-like release type, otherwise a burst-like release type emerges. Compared with a uniform microgel, the fuzzy-corona-like microgel enables a more productive drug release before reaching deswelling equilibrium. Our model not only predicts well the existing experiments, but also serves as a versatile paradigm to help understand the reciprocal roles of the solvent flow, the gel dynamics, and the diffusions in the polymer-based drug delivery systems.
分类号	二类/Q1
资助项目	National Science Foundation for Young Scientists of China ; [21903003]
WOS关键词	DELIVERY ; NANOPARTICLES ; POLYMERS
WOS研究方向	Chemistry ; Physics
语种	英语
WOS记录号	WOS:000893760100001
资助机构	National Science Foundation for Young Scientists of China
内容类型	期刊论文
源URL	[http://dspace.imech.ac.cn/handle/311007/91087]
专题	力学研究所_非线性力学国家重点实验室
推荐引用方式 GB/T 7714	Sui JZ. Osmotic release of drugs via deswelling dynamics of microgels: modeling of collaborative flow and diffusions[J]. PHYSICAL CHEMISTRY CHEMICAL PHYSICS,2022:9.
APA	隋济泽.(2022).Osmotic release of drugs via deswelling dynamics of microgels: modeling of collaborative flow and diffusions.PHYSICAL CHEMISTRY CHEMICAL PHYSICS,9.
MLA	隋济泽."Osmotic release of drugs via deswelling dynamics of microgels: modeling of collaborative flow and diffusions".PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2022):9.