Floating Ag-NPs@Cu-NW bundles fabricated on copper mesh for highly sensitive SERS detection of uric acid in pretreatment-free urine

doi:10.1039/d2an01586b

	Floating Ag-NPs@Cu-NW bundles fabricated on copper mesh for highly sensitive SERS detection of uric acid in pretreatment-free urine
	Song, Ziyan 1,2; Chen, Siyu 3; He, Qiushi 1,2; Liang, Hu 1,2; Huang, Guangyao 3; Li, Pan 3,4; Hao, Zongyao 1,2; Yang, Liangbao 3,4
刊名	ANALYST
	2022-12-05
卷号	147
ISSN号	0003-2654
DOI	10.1039/d2an01586b
通讯作者	Li, Pan(lipan2011@iim.ac.cn) ; Hao, Zongyao()
英文摘要	The rapid and sensitive detection of ultra-trace marker molecules from biological samples is of great significance for the wide application of surface-enhanced Raman spectroscopy (SERS) methods in clinical diagnosis and disease monitoring. However, the cumbersome biological sample processing procedures and the poor enrichment of target analytes in hot spots hinder the practical applications of SERS methods. In this paper, we synthesized a novel floating SERS substrate by a simple one-step oxidation process, annealing and in situ chemical etching to form Ag-NPs@Cu-NW bundles on copper mesh (CM). In particular, under spontaneous bottom-up capillary action, the pressure difference at different nanogaps drives uric acid molecules to actively enter hot spots, so that the Ag-NPs@Cu-NW bundle nanostructure with the advantages of a light weight CM is capable of preventing the common coffee-ring effect and enhancing the spatial enrichment of analytes. Therefore, this SERS substrate realizes highly sensitive detection of uric acid at a level of 50 nM in pretreatment-free urine. Currently, this portable, flexible, simple, fast and cost-effective SERS substrate has great potential for early screening and clinical diagnosis of diseases in different biofluids.
资助项目	National Natural Science Foundation of China ; Anhui Provincial Natural Science Foundation Project ; [82070724] ; [1908085MH246] ; [2208085MB31]
WOS关键词	ENHANCED RAMAN-SCATTERING ; SODIUM-BOROHYDRIDE ; SURFACE ; NANOWIRES ; WATER ; QUANTIFICATION ; PERFORMANCE ; CU(OH)(2) ; ARRAYS
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000888332700001
资助机构	National Natural Science Foundation of China ; Anhui Provincial Natural Science Foundation Project
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/131609]
专题	中国科学院合肥物质科学研究院
通讯作者	Li, Pan; Hao, Zongyao
作者单位	1.Anhui Med Univ, Affiliated Hosp 1, Dept Urol, Hefei, Peoples R China 2.Anhui Med Univ, Inst Urol & Anhui Prov Key Lab Genitourinary Dis, 218th Jixi Rd, Hefei 230022, Anhui, Peoples R China 3.Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Hefei 230031, Anhui, Peoples R China 4.Chinese Acad Sci, Hefei Canc Hosp, Dept Pharm, Hefei 230031, Anhui, Peoples R China
推荐引用方式 GB/T 7714	Song, Ziyan,Chen, Siyu,He, Qiushi,et al. Floating Ag-NPs@Cu-NW bundles fabricated on copper mesh for highly sensitive SERS detection of uric acid in pretreatment-free urine[J]. ANALYST,2022,147.
APA	Song, Ziyan.,Chen, Siyu.,He, Qiushi.,Liang, Hu.,Huang, Guangyao.,...&Yang, Liangbao.(2022).Floating Ag-NPs@Cu-NW bundles fabricated on copper mesh for highly sensitive SERS detection of uric acid in pretreatment-free urine.ANALYST,147.
MLA	Song, Ziyan,et al."Floating Ag-NPs@Cu-NW bundles fabricated on copper mesh for highly sensitive SERS detection of uric acid in pretreatment-free urine".ANALYST 147(2022).