Luteolin attenuated cisplatin-induced cardiac dysfunction and oxidative stress via modulation of Keap1/Nrf2 signaling pathway

doi:10.1080/10715762.2022.2067042

	Luteolin attenuated cisplatin-induced cardiac dysfunction and oxidative stress via modulation of Keap1/Nrf2 signaling pathway
	Qi, Yajun 1,2; Fu, Shuang 3,4; Pei, Donggen 5; Fang, Qilu 1,2; Xin, Wenxiu 1,2; Yuan, Xiaohong 3,4; Cao, Yingying 1,2; Shu, Qi 1,2; Mi, Xiufang 1,2; Luo, Fang 1,2
刊名	FREE RADICAL RESEARCH
	2022-04-23
关键词	Luteolin cisplatin oxidative stress Keap1 Nrf2
ISSN号	1071-5762
DOI	10.1080/10715762.2022.2067042
通讯作者	Qi, Yajun(qiyj@zjcc.org.cn) ; Luo, Fang(fangluo@zjcc.org.cn)
英文摘要	Cardiovascular complications are a well-documented limitation of cancer chemotherapy. Cisplatin-induced cardiotoxicity threatens the health and life of patients, and limits the application of cisplatin. Oxidative stress is the main mechanism underlying cisplatin-induced cardiac toxicity. Luteolin (Lut) has been reported to possess cardioprotective properties by activating nuclear factor-E2-related factor 2 (Nrf2) -mediated antioxidant response. However, the effect of Lut on cisplatin-induced cardiac damage remains unclear. In this study, we revealed that Lut exerted a protective effect against cisplatin-induced cardiac dysfunction and injury in vivo. In HL-1 cells, Lut was observed to dramatically reduce cisplatin-induced apoptosis and oxidative stress by modulating the Kelch-like epichlorohydrin-associated protein 1 (Keap1)/Nrf2 pathway. Altogether, these findings suggested that Lut showed promise in attenuating cisplatin-induced cardiac injury and might be considered a protective drug candidate for chemotherapy-associated cardiovascular complications.
资助项目	Medical Science and Technology Program of Zhejiang Province[2021431070] ; Medical Science and Technology Program of Zhejiang Province[2017190933]
WOS关键词	INDUCED CARDIOTOXICITY ; NRF2 ; PROGRESSION ; MECHANISMS ; INJURY ; AMPK
WOS研究方向	Biochemistry & Molecular Biology
语种	英语
出版者	TAYLOR & FRANCIS LTD
WOS记录号	WOS:000787225100001
资助机构	Medical Science and Technology Program of Zhejiang Province
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/131442]
专题	中国科学院合肥物质科学研究院
通讯作者	Qi, Yajun; Luo, Fang
作者单位	1.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Pharm, 38 Guangji Rd, Hangzhou 310022, Zhejiang, Peoples R China 2.Chinese Acad Sci, Inst Canc & Basic Med IBMC, Dept Pharm, Hangzhou, Zhejiang, Peoples R China 3.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Anesthesiol, Hangzhou, Zhejiang, Peoples R China 4.Chinese Acad Sci, Inst Canc & Basic Med IBMC, Dept Anesthesiol, Hangzhou, Zhejiang, Peoples R China 5.Nanjing Med Univ, Childrens Hosp, Dept Pharm, Nanjing, Peoples R China
推荐引用方式 GB/T 7714	Qi, Yajun,Fu, Shuang,Pei, Donggen,et al. Luteolin attenuated cisplatin-induced cardiac dysfunction and oxidative stress via modulation of Keap1/Nrf2 signaling pathway[J]. FREE RADICAL RESEARCH,2022.
APA	Qi, Yajun.,Fu, Shuang.,Pei, Donggen.,Fang, Qilu.,Xin, Wenxiu.,...&Luo, Fang.(2022).Luteolin attenuated cisplatin-induced cardiac dysfunction and oxidative stress via modulation of Keap1/Nrf2 signaling pathway.FREE RADICAL RESEARCH.
MLA	Qi, Yajun,et al."Luteolin attenuated cisplatin-induced cardiac dysfunction and oxidative stress via modulation of Keap1/Nrf2 signaling pathway".FREE RADICAL RESEARCH (2022).