A Portable Sensing Platform Using an Upconversion-Based Nanosensor for Visual Quantitative Monitoring of Mesna

doi:10.1021/acs.analchem.2c00380

	A Portable Sensing Platform Using an Upconversion-Based Nanosensor for Visual Quantitative Monitoring of Mesna
	Hu, Bin 1,3; Zhu, Jiawei 1,3; Shen, Jianjun 1,3; Yang, Liang 2,3; Jiang, Changlong 2,3
刊名	ANALYTICAL CHEMISTRY
	2022-05-31
卷号	94
ISSN号	0003-2700
DOI	10.1021/acs.analchem.2c00380
通讯作者	Yang, Liang(yangliang@iim.ac.cn) ; Jiang, Changlong(cljiang@iim.ac.cn)
英文摘要	Mesna is an important regional antidote for protecting the urinary system of chemotherapy patients, which requires monitoring its level in real time to ensure the curative effect. The fluorescence method is a powerful tool in real-time detection with the advantages of fast response and visualization. However, the background interference limits its application in biological sensing. Here, we developed a portable sensing platform using an upconversion-based nano-sensor for visual quantitative monitoring of mesna in real-time/on-site conditions. The nanosensor was constructed by upconversion nanoparticles (UCNPs) and ethyl violet (EV), in which the UCNPs emitted red and green light, while EV quenched the green light due to the inner filter effect (IFE). The reaction of mesna with EV caused its fading and broke the IFE process, leading to the recovery of green light. By the fluorescence and colorimetric chromaticity variations, the nanosensor achieved a dual-readout detection for mesna with low limits of detection (LODs) of 26 and 48 nM, respectively. Furthermore, a highly compatible sensing platform was fabricated for facile determination of mesna with an LOD of 56 nM, realizing visual quantitative monitoring of the mesna level to ensure the curative effect and providing a new strategy for point-of-care testing of drugs in clinical settings.
资助项目	National Natural Science Foundation of China[21876175] ; National Key Research and Development Program[2021YFD2000200] ; Key Research and Development Program of Anhui Province[202004d07020013]
WOS关键词	INDUCED HEMORRHAGIC CYSTITIS ; REACTIVE OXYGEN ; CYCLOPHOSPHAMIDE ; DOXORUBICIN ; IFOSFAMIDE ; TISSUE ; ACID
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000807338400015
资助机构	National Natural Science Foundation of China ; National Key Research and Development Program ; Key Research and Development Program of Anhui Province
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/131277]
专题	中国科学院合肥物质科学研究院
通讯作者	Yang, Liang; Jiang, Changlong
作者单位	1.Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China 2.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab Photovolta & Energy Conservat Mat, Hefei 230031, Peoples R China 3.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Solid State Phys, Hefei 230031, Anhui, Peoples R China
推荐引用方式 GB/T 7714	Hu, Bin,Zhu, Jiawei,Shen, Jianjun,et al. A Portable Sensing Platform Using an Upconversion-Based Nanosensor for Visual Quantitative Monitoring of Mesna[J]. ANALYTICAL CHEMISTRY,2022,94.
APA	Hu, Bin,Zhu, Jiawei,Shen, Jianjun,Yang, Liang,&Jiang, Changlong.(2022).A Portable Sensing Platform Using an Upconversion-Based Nanosensor for Visual Quantitative Monitoring of Mesna.ANALYTICAL CHEMISTRY,94.
MLA	Hu, Bin,et al."A Portable Sensing Platform Using an Upconversion-Based Nanosensor for Visual Quantitative Monitoring of Mesna".ANALYTICAL CHEMISTRY 94(2022).