Stress in DNA Gridiron Facilitates the Formation of Two-Dimensional Crystalline Structures

doi:10.1021/jacs.2c02009

	Stress in DNA Gridiron Facilitates the Formation of Two-Dimensional Crystalline Structures
	Yu, Lei 1,2,6; Cheng, Jin 5; Wang, Dongfang 2,6; Pan, Victor 2,6; Chang, Shuai 1; Song, Jie 3,4,5; Ke, Yonggang 2,6
刊名	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
	2022-06-08
卷号	144
ISSN号	0002-7863
DOI	10.1021/jacs.2c02009
通讯作者	Chang, Shuai(schang23@wust.edu.cn) ; Song, Jie(sjie@sjtu.edu.cn) ; Ke, Yonggang(yonggang.ke@emory.edu)
英文摘要	Programmable DNA nanotechnology has generated some of the most intricate self-assembled nanostructures and has been employed in a growing number of applications, including functional nanomaterials, nanofabrication, biophysics, photonics, molecular machines, and drug delivery. An important design rule for DNA nanostructures is to minimize the mechanical stress to reduce the potential energy in these nanostructures whenever it is possible. This work revisits the DNA gridiron design consisting of Holliday junctions and compares the self-assembly of the canonical DNA gridiron with a new design of DNA gridiron, which has a higher degree of mechanical stress because of the interweaving of DNA helices. While the interweaving DNA gridiron indeed exhibits lower yield, compared to its canonical counterpart of a similar size, we discover that the mechanical stress within the interweaving gridiron can promote the formation of the twodimensional crystalline lattice instead of nanotubes. Furthermore, tuning the design of interweaving gridiron leads to the change of overall crystal size and regularity of geometry. Interweaving DNA double helices represents a new design strategy in the self-assembly of DNA nanostructures. Furthermore, the discovery of the new role of mechanical stress in the self-assembly of DNA nanostructures provides useful knowledge to DNA nanotechnology practitioners: a more balanced view regarding mechanical stress can be considered when designing future DNA nanostructures.
资助项目	National Science Foundation[DMR-1654485] ; Outstanding Young and Middle-aged Team in Colleges of Hubei Province of China[T2021002] ; National Natural Science Foundation of China[22161132008] ; Starry Night Science Fund of Zhejiang University Shanghai Institute for Advanced Study[SN-ZJU-SIAS-006]
WOS关键词	FOLDING DNA ; DESIGN ; ORIGAMI ; ARRAYS
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000809993400001
资助机构	National Science Foundation ; Outstanding Young and Middle-aged Team in Colleges of Hubei Province of China ; National Natural Science Foundation of China ; Starry Night Science Fund of Zhejiang University Shanghai Institute for Advanced Study
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/131271]
专题	中国科学院合肥物质科学研究院
通讯作者	Chang, Shuai; Song, Jie; Ke, Yonggang
作者单位	1.Wuhan Univ Sci & Technol, Inst Adv Mat & Nanotechnol, State Key Lab Refractories & Met, Wuhan 430081, Hubei, Peoples R China 2.Emory Univ, Atlanta, GA 30322 USA 3.Univ Chinese Acad Sci, Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China 4.Chinese Acad Sci, Inst Basic Med & Canc IBMC, Hangzhou 310022, Zhejiang, Peoples R China 5.Shanghai Jiao Tong Univ, Sch Elect Informat & Elect Engn, Dept Instrument Sci & Engn, Inst Nano Biomed & Engn, Shanghai 200240, Peoples R China 6.Georgia Inst Technol, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30322 USA
推荐引用方式 GB/T 7714	Yu, Lei,Cheng, Jin,Wang, Dongfang,et al. Stress in DNA Gridiron Facilitates the Formation of Two-Dimensional Crystalline Structures[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2022,144.
APA	Yu, Lei.,Cheng, Jin.,Wang, Dongfang.,Pan, Victor.,Chang, Shuai.,...&Ke, Yonggang.(2022).Stress in DNA Gridiron Facilitates the Formation of Two-Dimensional Crystalline Structures.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,144.
MLA	Yu, Lei,et al."Stress in DNA Gridiron Facilitates the Formation of Two-Dimensional Crystalline Structures".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 144(2022).