Chronic graft-versus-host disease-related polymyositis and myocarditis: A case report and review of the literature

doi:10.1016/j.trim.2022.101598

	Chronic graft-versus-host disease-related polymyositis and myocarditis: A case report and review of the literature
	Yan, Mengni 3,4; Su, Fengqin 3,4; Cheng, Fei 1; Shi, Jimin 3,4; Zheng, Weiyan 3,4; Luo, Yi 3,4; Wang, Jianwen 1; Lu, Hui 1; Zhou, Haiying 1; Huang, He 3,4
刊名	TRANSPLANT IMMUNOLOGY
	2022-06-01
卷号	72
关键词	Hematopoietic stem cell transplantation Chronic graft-versus-host disease Polymyositis Myocarditis
ISSN号	0966-3274
DOI	10.1016/j.trim.2022.101598
通讯作者	Tan, Yamin(yamin0001@126.com)
英文摘要	Chronic graft-versus-host disease (cGVHD) is a major late complication of hematopoietic stem cell transplantation (HSCT). Polymyositis (PM) has been reported to be an uncommon presentation of cGVHD. Myocarditis is an even rarer manifestation of cGVHD-associated PM. Here, we report a 38-year-old male patient developed cGVHD-related PM twelve years post-transplantation, which was confirmed by muscle biopsy and immunological study. The presence of pain in the chest area, dynamic changes in the electrocardiogram, as well as elevated troponin and myocardial enzyme levels with improvement after immunotherapy all pointed to cardiac involvement. Ruxolitinib in combination with tachlimus and methylprednisolone successfully treated cGVHD associated PM with myocarditis. The literature on cGVHD-related PM and myocarditis is briefly reviewed.
资助项目	National Natural Science Founda-tion of China[81970137]
WOS关键词	MANIFESTATION
WOS研究方向	Immunology ; Transplantation
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000793763900003
资助机构	National Natural Science Founda-tion of China
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/130943]
专题	中国科学院合肥物质科学研究院
通讯作者	Tan, Yamin
作者单位	1.Zhejiang Univ, Affiliated Hosp 1, Sch Med, Hangzhou, Peoples R China 2.Chinese Acad Sci, Hematol Dept, Canc Hosp,Inst Basic Med & Canc IBMC, Univ Chinese Acad Sci,Zhejiang Canc Hosp, Hangzhou, Peoples R China 3.Zhejiang Univ, Bone Marrow Transplantat Ctr, Affiliated Hosp 1, Sch Med, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China 4.Zhejiang Univ, Inst Hematol, Hangzhou, Peoples R China
推荐引用方式 GB/T 7714	Yan, Mengni,Su, Fengqin,Cheng, Fei,et al. Chronic graft-versus-host disease-related polymyositis and myocarditis: A case report and review of the literature[J]. TRANSPLANT IMMUNOLOGY,2022,72.
APA	Yan, Mengni.,Su, Fengqin.,Cheng, Fei.,Shi, Jimin.,Zheng, Weiyan.,...&Tan, Yamin.(2022).Chronic graft-versus-host disease-related polymyositis and myocarditis: A case report and review of the literature.TRANSPLANT IMMUNOLOGY,72.
MLA	Yan, Mengni,et al."Chronic graft-versus-host disease-related polymyositis and myocarditis: A case report and review of the literature".TRANSPLANT IMMUNOLOGY 72(2022).