Weizmannia coagulans BC2000 Plus Ellagic Acid Inhibits High-Fat-Induced Insulin Resistance by Remodeling the Gut Microbiota and Activating the Hepatic Autophagy Pathway in Mice

doi:10.3390/nu14194206

	Weizmannia coagulans BC2000 Plus Ellagic Acid Inhibits High-Fat-Induced Insulin Resistance by Remodeling the Gut Microbiota and Activating the Hepatic Autophagy Pathway in Mice
	Jin, Long 2,3,4; Dang, Hongyang 1,5; Wu, Jinyong 2; Yuan, Lixia 2; Chen, Xiangsong 2; Yao, Jianming 2,3
刊名	NUTRIENTS
	2022-10-01
卷号	14
关键词	Weizmannia coagulans ellagic acid high-fat diet insulin resistance gut microbiota autophagy
DOI	10.3390/nu14194206
通讯作者	Chen, Xiangsong(xschen@ipp.cas.cn) ; Yao, Jianming(jmy63@ipp.ac.cn)
英文摘要	(1) Background: Ellagic acid (EA) acts as a product of gut microbiota transformation to prevent insulin resistance, which is limited by high-fat diet (HFD)-induced dysbiosis. The aim of this study was to investigate the synergistic effects and mechanisms of supplementation with the probiotic Weizmannia coagulans (W. coagulans) on the prevention of insulin resistance by EA; (2) Methods: C57BL/6J mice were divided into five groups (n = 10/group): low-fat-diet group, high-fat-diet group, EA intervention group, EA + W. coagulans BC77 group, and EA + W. coagulans BC2000 group; (3) Result: W. coagulans BC2000 showed a synergistic effect on EA's lowering insulin resistance index and inhibiting high-fat diet-induced endotoxemia. The combined effect of BC2000 and EA activated the autophagy pathway in the mouse liver, a urolithin-like effect. This was associated with altered beta-diversity of gut microbiota and increased Eggerthellaceae, a potential EA-converting family. Ellagic acid treatment alone and the combined use of ellagic acid and W. coagulans BC77 failed to activate the hepatic autophagy pathway; (4) Conclusions: W. coagulans BC2000 can assist EA in its role of preventing insulin resistance. This study provides a basis for the development of EA-rich functional food supplemented with W. coagulans BC2000.
资助项目	Probiotics Research Institute Coconstruction Agreement of the Chinese Academy of Sciences ; Chacha Food Co., Ltd.[GLHTSP-2019001002]
WOS关键词	BACILLUS-COAGULANS ; SP-NOV. ; UROLITHIN ; INFLAMMATION ; MITOPHAGY ; SURVIVAL ; HEALTH ; MODEL
WOS研究方向	Nutrition & Dietetics
语种	英语
出版者	MDPI
WOS记录号	WOS:000866996200001
资助机构	Probiotics Research Institute Coconstruction Agreement of the Chinese Academy of Sciences ; Chacha Food Co., Ltd.
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/129263]
专题	中国科学院合肥物质科学研究院
通讯作者	Chen, Xiangsong; Yao, Jianming
作者单位	1.Qingdao Univ, Inst Nutr & Hlth, Qingdao 266021, Peoples R China 2.Chinese Acad Sci, Inst Plasma Phys, Hefei Inst Phys Sci, Hefei 230031, Peoples R China 3.Univ Sci & Technol China, Hefei 230026, Peoples R China 4.Probiot Inst, Hefei 230031, Peoples R China 5.Xinjiang Univ, Coll Life Sci & Technol, Urumqi 830046, Peoples R China
推荐引用方式 GB/T 7714	Jin, Long,Dang, Hongyang,Wu, Jinyong,et al. Weizmannia coagulans BC2000 Plus Ellagic Acid Inhibits High-Fat-Induced Insulin Resistance by Remodeling the Gut Microbiota and Activating the Hepatic Autophagy Pathway in Mice[J]. NUTRIENTS,2022,14.
APA	Jin, Long,Dang, Hongyang,Wu, Jinyong,Yuan, Lixia,Chen, Xiangsong,&Yao, Jianming.(2022).Weizmannia coagulans BC2000 Plus Ellagic Acid Inhibits High-Fat-Induced Insulin Resistance by Remodeling the Gut Microbiota and Activating the Hepatic Autophagy Pathway in Mice.NUTRIENTS,14.
MLA	Jin, Long,et al."Weizmannia coagulans BC2000 Plus Ellagic Acid Inhibits High-Fat-Induced Insulin Resistance by Remodeling the Gut Microbiota and Activating the Hepatic Autophagy Pathway in Mice".NUTRIENTS 14(2022).