Self-assembled Pt(II) metallacycles enable precise cancer combination chemotherapy

doi:10.1073/pnas.2202255119

	Self-assembled Pt(II) metallacycles enable precise cancer combination chemotherapy
	Zhang, Pengge 1; Zhou, Zhixuan 2; Long, Wen 3; Yan, Yuping 1; Li, Youshan 1; Fu, Ting 1,4; Liu, Yanlan 1; Zhao, Zilong 1; Tan, Weihong 1,4,5,6; Stang, Peter J.2
刊名	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
	2022-05-17
卷号	119
关键词	self-assembly supramolecular coordination complex combination chemotherapy targeted cancer therapy drug delivery
ISSN号	0027-8424
DOI	10.1073/pnas.2202255119
通讯作者	Zhao, Zilong(zlzhao@hnu.edu.cn) ; Tan, Weihong(tan@hnu.edu.cn) ; Stang, Peter J.(stang@chem.utah.edu)
英文摘要	Combination chemotherapy, which involves the simultaneous use of multiple anticancer drugs in adequate combinations to disrupt multiple mechanisms associated with tumor growth, has shown advantages in enhanced therapeutic efficacy and lower systemic toxicity relative to monotherapy. Herein, we employed coordination-driven self-assembly to construct discrete Pt(II) metallacycles as monodisperse, modular platforms for combining camptothecin and combretastatin A4, two chemotherapy agents with a disparate mechanism of action, in precise arrangements for combination chemotherapy. Formulation of the drug-loaded metallacycles with folic acid-functionalized amphiphilic diblock copolymers furnished nanoparticles with good solubility and stability in physiological conditions. Folic acids on the surface of the nanoparticles promote their internalization into cancer cells. The intracellular reductive environment of cancer cells induces the release of the drug molecules at an exact 1:1 ratio, leading to a synergistic anticancer efficacy. In vivo studies on tumor-bearing mice demonstrated the favorable therapeutic outcome and minimal side effects of the combination chemotherapy approach based on a self-assembled metallacycle.
资助项目	National Key Research and Development Program[2021YFA0910000] ; National Natural Science Foundation of China[21974040] ; National Natural Science Foundation of China[22177028]
WOS关键词	DRUG ; CAGES ; FUNCTIONALIZATION ; FLUORESCENCE ; METALLACAGES ; DELIVERY ; PRODRUG
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	NATL ACAD SCIENCES
WOS记录号	WOS:000854008900012
资助机构	National Key Research and Development Program ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/128998]
专题	中国科学院合肥物质科学研究院
通讯作者	Zhao, Zilong; Tan, Weihong; Stang, Peter J.
作者单位	1.Hunan Univ, Coll Chem & Chem Engn, Aptamer Engn Ctr Hunan Prov, Mol Sci & Biomed Lab MBL,State Key Lab Chemo Bios, Changsha 410082, Peoples R China 2.Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA 3.Hunan Normal Univ, Dept Chem & Chem Engn, Changsha 410081, Peoples R China 4.Chinese Acad Sci, Zhejiang Canc Hosp, Univ Chinese Acad Sci, Canc Hosp,Hangzhou Inst Med HIM, Hangzhou 310022, Peoples R China 5.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Inst Mol Med IMM, Shanghai 200240, Peoples R China 6.Shanghai Jiao Tong Univ, Coll Chem & Chem Engn, Shanghai 200240, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Pengge,Zhou, Zhixuan,Long, Wen,et al. Self-assembled Pt(II) metallacycles enable precise cancer combination chemotherapy[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2022,119.
APA	Zhang, Pengge.,Zhou, Zhixuan.,Long, Wen.,Yan, Yuping.,Li, Youshan.,...&Stang, Peter J..(2022).Self-assembled Pt(II) metallacycles enable precise cancer combination chemotherapy.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,119.
MLA	Zhang, Pengge,et al."Self-assembled Pt(II) metallacycles enable precise cancer combination chemotherapy".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 119(2022).