Characterizations of Alpha-Cellulose and Microcrystalline Cellulose Isolated from Cocoa Pod Husk as a Potential Pharmaceutical Excipient

doi:10.3390/ma15175992

	Characterizations of Alpha-Cellulose and Microcrystalline Cellulose Isolated from Cocoa Pod Husk as a Potential Pharmaceutical Excipient
	Adeleye, Olutayo A.1,5; Bamiro, Oluyemisi A.2; Albalawi, Doha A.3; Alotaibi, Amenah S.4; Iqbal, Haroon 6; Sanyaolu, Saheed 2; Femi-Oyewo, Mbang N.1; Sodeinde, Kehinde O.7; Yahaya, Zwanden S.8; Thiripuranathar, Gobika 9
刊名	MATERIALS
	2022-09-01
卷号	15
关键词	alpha cellulose microcrystalline cellulose cocoa pod husk direct compression metronidazole tablet
DOI	10.3390/ma15175992
通讯作者	Adeleye, Olutayo A.(olutayo.adeleye@fuoye.edu.ng) ; Menaa, Farid(menaateam@gmail.com)
英文摘要	Cellulose is a non-toxic, bio-degradable, and renewable biopolymer which is abundantly available in nature. The most common source of commercial microcrystalline cellulose is fibrous wood pulp. Cellulose and its derivatives have found wide commercial applications in the pharmaceutical, cosmetic, food, paper, textile, and engineering industries. This study aims to isolate and characterize cellulose forms from cocoa pod husk (CPH) and to assess its mechanical and disintegration properties as a direct compression excipient in metronidazole tablets. Two isolated cellulose types (i.e., cocoa alpha-cellulose (CAC) and cocoa microcrystalline cellulose (C-MCC)) were compared with avicel (AV). CAC and C-MCC were characterized for their physicochemical properties using Scanning Electron Microscopy (SEM), FTIR spectroscopy, Differential Scanning Calorimetry (DSC), and X-Ray Powder Diffraction (XRD). Metronidazole tablets were produced by direct compression with cellulose. The mechanical and disintegration properties of the tablets were evaluated. CAC and C-MCC yield was 42.3% w/w and 38.25% w/w, respectively. Particle diameters were significantly different with CAC (282.22 mu m) > C-MCC (161.32 mu m) > AV (72.51 mu m). CAC and C-MCC had a better flow than AV. SEM revealed the fibrous nature of the cellulose. FTIR and XRD analysis confirmed the presence of cellulose with crystallinity index of 69.26%, 43.83%, and 26.32% for AV, C-MCC, and CAC, respectively. C-MCC and AV are more crystalline and thermally stable at high temperatures compared to CAC. The mechanical and disintegration properties of C-MCC and AV tablets complied with pharmacopeia specifications. Taken together, C-MCC isolated from CPH displayed some fundamental characteristics suitable for use as a pharmaceutical excipient and displayed better properties compared to that of AV.
WOS关键词	NANOCRYSTALS ; FIBERS ; CRYSTALLINITY ; EXTRACTION ; BIOMASS ; ENERGY ; FLOW
WOS研究方向	Chemistry ; Materials Science ; Metallurgy & Metallurgical Engineering ; Physics
语种	英语
出版者	MDPI
WOS记录号	WOS:000851795600001
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/128822]
专题	中国科学院合肥物质科学研究院
通讯作者	Adeleye, Olutayo A.; Menaa, Farid
作者单位	1.Afe Babalola Univ, Coll Pharm, Dept Pharmaceut & Pharmaceut Technol, Ado Ekiti 360101, Ekiti State, Nigeria 2.Olabisi Onabanjo Univ, Dept Pharmaceut & Pharmaceut Technol, Ago Iwoye 120107, Ogun State, Nigeria 3.Univ Tabuk, Fac Sci, Dept Biol, Tabuk 71491, Saudi Arabia 4.Univ Tabuk, Fac Sci, Dept Biol, Genom & Biotechnol Unit, Tabuk 71491, Saudi Arabia 5.Fed Univ Oye Ekiti, Dept Pharmaceut & Pharmaceut Technol, Oye Ekiti 3600001, Ekiti State, Nigeria 6.Chinese Acad Sci, Univ Chinese Acad Sci, Inst Basic Med & Canc IBMC, Zhejiang Canc Hosp,Canc Hosp, Hangzhou 310022, Peoples R China 7.Fed Univ Oye Ekiti, Dept Ind Chem, Oye Ekiti 3600001, Ekiti State, Nigeria 8.Kaduna State Univ, Dept Pharmaceut & Ind Pharm, Kabala Coastain 800283, Kaduna State, Nigeria 9.Coll Chem Sci, Inst Chem Ceylon, Rajagiriya 10107, Sri Lanka 10.Fluorotron Inc, Dept Pharmaceut & Nanomed, San Diego, CA 92037 USA
推荐引用方式 GB/T 7714	Adeleye, Olutayo A.,Bamiro, Oluyemisi A.,Albalawi, Doha A.,et al. Characterizations of Alpha-Cellulose and Microcrystalline Cellulose Isolated from Cocoa Pod Husk as a Potential Pharmaceutical Excipient[J]. MATERIALS,2022,15.
APA	Adeleye, Olutayo A..,Bamiro, Oluyemisi A..,Albalawi, Doha A..,Alotaibi, Amenah S..,Iqbal, Haroon.,...&Menaa, Farid.(2022).Characterizations of Alpha-Cellulose and Microcrystalline Cellulose Isolated from Cocoa Pod Husk as a Potential Pharmaceutical Excipient.MATERIALS,15.
MLA	Adeleye, Olutayo A.,et al."Characterizations of Alpha-Cellulose and Microcrystalline Cellulose Isolated from Cocoa Pod Husk as a Potential Pharmaceutical Excipient".MATERIALS 15(2022).