Tabersonine inhibits the lipopolysaccharide induced neuroinflammatory response in BV2 microglia cells via the NF-κB signaling pathway | |
Jiao-Tai Shi4; Cheng-Bo Wang3; Chun-Yan Sang3; Stanislas Nsanzamahoro2,3; Tian Chai3; Jun Wang1; Ai-Mei Yang4; Jun-Li Yang3 | |
刊名 | Molecules |
2022 | |
期号 | 27页码:7521 |
关键词 | tabersonine neuroinflammation lipopolysaccharide BV2 NF-kB signaling pathway |
DOI | 10.3390/molecules27217521 |
英文摘要 | The occurrence and development of neurodegenerative diseases is related to a variety of physiological and pathological changes. Neuroinflammation is one of the major factors that induces and aggravates neurodegenerative diseases. The most important manifestation of neuroinflammation is the activation of microglia. Therefore, inhibiting the abnormal activation of microglia is an important way to alleviate the occurrence of neuroinflammatory diseases. In this research, the inhibitory effect of tabersonine (Tab) on neuroinflammation was evaluated by establishing the BV2 neuroinflammation model induced by lipopolysaccharide (LPS). It was found that Tab significantly inhibited the production and expression of nitric oxide (NO), interleukin-1b (IL-1b), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and reactive oxygen species (ROS) in BV-2 cells stimulated by LPS. In addition, Tab can also inhibit the activation of nuclear factor-kB (NF- κ B) induced by LPS, thus regulating inflammatory mediators such as inducible nitric oxide synthase (iNOS). These results indicated that Tab regulated the release of inflammatory mediators such as NO, IL-1b, TNF-_, and IL-6 by inhibiting NF-kB signaling pathway, and exerting its anti-neuroinflammatory effect. This is the first report regarding the inhibition on LPS-induced neuroinflammation in BV2 microglia cells of Tab, which indicated the drug development potential of Tab for the treatment of neurodegenerative diseases. |
内容类型 | 期刊论文 |
源URL | [http://ir.licp.cn/handle/362003/29254] |
专题 | 兰州化学物理研究所_中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
通讯作者 | Ai-Mei Yang; Jun-Li Yang |
作者单位 | 1.Shandong Laboratory of Yantai Advanced Materials and Green Manufacturing 2.University of Chinese Academy of Sciences 3.Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences 4.School of Life Science and Engineering, Lanzhou University of Technology |
推荐引用方式 GB/T 7714 | Jiao-Tai Shi,Cheng-Bo Wang,Chun-Yan Sang,et al. Tabersonine inhibits the lipopolysaccharide induced neuroinflammatory response in BV2 microglia cells via the NF-κB signaling pathway[J]. Molecules,2022(27):7521. |
APA | Jiao-Tai Shi.,Cheng-Bo Wang.,Chun-Yan Sang.,Stanislas Nsanzamahoro.,Tian Chai.,...&Jun-Li Yang.(2022).Tabersonine inhibits the lipopolysaccharide induced neuroinflammatory response in BV2 microglia cells via the NF-κB signaling pathway.Molecules(27),7521. |
MLA | Jiao-Tai Shi,et al."Tabersonine inhibits the lipopolysaccharide induced neuroinflammatory response in BV2 microglia cells via the NF-κB signaling pathway".Molecules .27(2022):7521. |
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