Controllable assembly metal-organic frameworks and gold nanoparticles composites for sensitive immunochromatographic assay

	Controllable assembly metal-organic frameworks and gold nanoparticles composites for sensitive immunochromatographic assay
	Yin, XC; Dou, LN; Yao, XL; Liu, SJ; Zhang, L; Zhao, M; Su, LH; Sun, J; Wang, JL; Zhang, DH
刊名	FOOD CHEMISTRY
	2021
卷号	367
英文摘要	Creating universal signal labels from fundamental building blocks with excellent biocompatibility and wellcontrolled size/uniformity simultaneously for immunochromatographic assay (ICA) is highly desired but extremely challenging. Here, a nano-signal label strategy was reported, in which the amino-terminated zirconium MOFs (NU66) are adopted to construct powerful matrix materials and gold nanoparticles (AuNPs) act as the linker between metal-organic frameworks (MOFs) and antibodies. Particularly, AuNPs were immobilized directly on the surface of NU66, giving NU66 excellent biocompatibility with bright color signal labels and improving the salt ion stability of AuNPs. As a proof of concept, the furazolidone residues was monitored by the developed NU66@AuNPs-ICA in food samples (pork, shrimp and eggs). With 3-[(4-carboxyphenyl) monomethyl] amino-2oxazolidinone (CPAOZ) as analyte target, the visual limit of detection (vLOD) and cut-off level were 0.6 ng/mL and 3.0 ng/mL, respectively. This work may open a new avenue for the application of MOFs in immunochromatography assays.
内容类型	期刊论文
源URL	[http://210.75.249.4/handle/363003/61371]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Yin, XC,Dou, LN,Yao, XL,et al. Controllable assembly metal-organic frameworks and gold nanoparticles composites for sensitive immunochromatographic assay[J]. FOOD CHEMISTRY,2021,367.
APA	Yin, XC.,Dou, LN.,Yao, XL.,Liu, SJ.,Zhang, L.,...&Zhang, DH.(2021).Controllable assembly metal-organic frameworks and gold nanoparticles composites for sensitive immunochromatographic assay.FOOD CHEMISTRY,367.
MLA	Yin, XC,et al."Controllable assembly metal-organic frameworks and gold nanoparticles composites for sensitive immunochromatographic assay".FOOD CHEMISTRY 367(2021).