Exploring the mechanisms of action of Cordyceps sinensis for the treatment of depression using network pharmacology and molecular docking

	Exploring the mechanisms of action of Cordyceps sinensis for the treatment of depression using network pharmacology and molecular docking
	Zhang, XF; Wang, MY; Qiao, YJ; Shan, ZS; Yang, MM; Li, GQ; Xiao, YC; Wei, LX; Bi, HT; Gao, TT
刊名	ANNALS OF TRANSLATIONAL MEDICINE
	2022
卷号	10 期号:6
英文摘要	Background: Depression is the most common type of psychological disorder, with continuous, prolonged, and persistent bad moods as the main clinical feature. Cordyceps sinensis is a complex consisting of the ascospores and bodies of insect larvae from the Hepialidae family that have been parasitized by Cordyceps sinensis militaris. Previous studies have reported that this herb has antidepressant activity. The present study used network pharmacology and molecular docking techniques to investigate the potential antidepressant mechanisms of Cordyceps sinensis. Methods: The active ingredients of Cordyceps sinensis were identified using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) and the potential targets were predicted using the PharmMapper platform. The GeneCards database was then used to obtain sub-targets for depression. Common targets were screened and enrichment analyses were performed using the Metascape platform. Finally, the relationship between the active ingredients and the core targets were verified by molecular docking. Results: Through network pharmacological analysis, 7 active ingredients in Cordyceps sinensis and 41 common targets of drugs and diseases were identified. The active ingredients of Cordyceps sinensis may exert antidepressant effects by acting on important targets such as catalase (CAT), CREB binding protein (CREBBP), epidermal growth factor (EGF), and E1A binding protein P300 (EP300), and by modulating the signaling pathways in which these targets are involved. Subsequently, the core targets were docked to the active ingredients and good binding was observed. Conclusions: The active ingredients of Cordyceps sinensis may exert antidepressant effects by regulating the CREB binding protein and anti-oxidative stress effects. The foxo signaling pathway (hsa04068), hypoxia-inducible factor 1 (HIF-1) signaling pathway (hsa04066), and Huntington's disease (hsa05016) may be involved in the underlying mechanisms of Cordyceps sinensis. The joint application of network pharmacology
内容类型	期刊论文
源URL	[http://210.75.249.4/handle/363003/61270]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Zhang, XF,Wang, MY,Qiao, YJ,et al. Exploring the mechanisms of action of Cordyceps sinensis for the treatment of depression using network pharmacology and molecular docking[J]. ANNALS OF TRANSLATIONAL MEDICINE,2022,10(6).
APA	Zhang, XF.,Wang, MY.,Qiao, YJ.,Shan, ZS.,Yang, MM.,...&Gao, TT.(2022).Exploring the mechanisms of action of Cordyceps sinensis for the treatment of depression using network pharmacology and molecular docking.ANNALS OF TRANSLATIONAL MEDICINE,10(6).
MLA	Zhang, XF,et al."Exploring the mechanisms of action of Cordyceps sinensis for the treatment of depression using network pharmacology and molecular docking".ANNALS OF TRANSLATIONAL MEDICINE 10.6(2022).