Insights Into miRNA-mRNA Regulatory Mechanisms of Cold Adaptation in Gymnocypris eckloni: Ubiquitin-Mediated Proteolysis Is Pivotal for Adaptive Energy Metabolism
Nie, MM; Ni, WL; Wang, LH; Gao, Q; Liu, D; Tian, F; Wang, ZJ; Zhang, CF; Qi, DL
刊名FRONTIERS IN GENETICS
2022
卷号13
英文摘要This study aimed to understand cold stress adaptations mechanism in fish. Thus, the transcriptional response to cold conditions in Gymnocypris eckloni was evaluated using RNA-seq and microRNA (miRNA)-seq analyses. Low-temperature (LT) group G. eckloni was cultivated outdoors in waters cooled to 2-4 degrees C for 3 weeks, while individuals in the control temperature (CT) group were exposed to 14-16 degrees C. Significantly different responses were observed in both mRNA and miRNA expression profiles, with more mRNAs (1,833 and 1,869 mRNAs were up- and downregulated, respectively) and fewer miRNAs (15 and 6 were up- and downregulated, respectively) observed in the LT group individuals relative to the CT group individuals. A miRNA-mRNA network involved in the regulation of G. eckloni responses to cold stress was constructed; this network included ubiquitin-mediated proteolysis, protein processing, and oxidative phosphorylation. These results provided new insights into mechanisms of cold tolerance by fish, including decreased metabolic activity in addition to proteolysis.
内容类型期刊论文
源URL[http://210.75.249.4/handle/363003/61149]  
专题西北高原生物研究所_中国科学院西北高原生物研究所
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GB/T 7714
Nie, MM,Ni, WL,Wang, LH,et al. Insights Into miRNA-mRNA Regulatory Mechanisms of Cold Adaptation in Gymnocypris eckloni: Ubiquitin-Mediated Proteolysis Is Pivotal for Adaptive Energy Metabolism[J]. FRONTIERS IN GENETICS,2022,13.
APA Nie, MM.,Ni, WL.,Wang, LH.,Gao, Q.,Liu, D.,...&Qi, DL.(2022).Insights Into miRNA-mRNA Regulatory Mechanisms of Cold Adaptation in Gymnocypris eckloni: Ubiquitin-Mediated Proteolysis Is Pivotal for Adaptive Energy Metabolism.FRONTIERS IN GENETICS,13.
MLA Nie, MM,et al."Insights Into miRNA-mRNA Regulatory Mechanisms of Cold Adaptation in Gymnocypris eckloni: Ubiquitin-Mediated Proteolysis Is Pivotal for Adaptive Energy Metabolism".FRONTIERS IN GENETICS 13(2022).
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