Structural and functional dysbiosis of gut microbiota in Tibetan subjects with coronary heart disease

	Structural and functional dysbiosis of gut microbiota in Tibetan subjects with coronary heart disease
	Cheng, Q; Fan, C; Liu, FY; Li, Y; Hou, HW; Ma, Y; Tan, YQ; Li, YX; Hai, Y; Wu, TY
刊名	GENOMICS
	2022
卷号	114 期号:6
英文摘要	The gut microbiota plays a crucial role in coronary heart disease (CHD). However, only a few studies focusing on the relationship between gut microbiota and CHD in ethnic populations are available. Here, we employed shotgun sequencing of the gut metagenome to analyze the taxonomic composition and functional annotation of the gut microbiota of 14 CHD patients, 13 patients with non-stenosis coronary heart disease (NCHD), and 18 healthy controls (HT) in Tibetan subjects. We found that the alpha-diversity of the gut microbiota was not signifi-cantly different among the three groups., whereas beta-diversity was significantly altered in the CHD group compared with HT. Based on the receiver operating characteristic curve (ROC) analysis, the relative abundance of Proteobacteria species effectively distinguished patients with CHD from the control group. Most of the enriched species belonged to Proteobacteria. The pathways that contributed the most to the differences between groups were amino acid metabolism-related pathways, especially lysine biosynthesis. The enzymes of the lysine biosynthesis pathway, including K01714 and K00821, were significantly decreased in the CHD group. Our findings increase the understanding of the association between CHD pathogenesis and gut microbiota in the Tibetan population, thus paving the way for the development of improved diagnostic methods and treatments for Tibetan patients with CHD.
内容类型	期刊论文
源URL	[http://210.75.249.4/handle/363003/61060]
专题	西北高原生物研究所_中国科学院西北高原生物研究所
推荐引用方式 GB/T 7714	Cheng, Q,Fan, C,Liu, FY,et al. Structural and functional dysbiosis of gut microbiota in Tibetan subjects with coronary heart disease[J]. GENOMICS,2022,114(6).
APA	Cheng, Q.,Fan, C.,Liu, FY.,Li, Y.,Hou, HW.,...&Zhang, YM.(2022).Structural and functional dysbiosis of gut microbiota in Tibetan subjects with coronary heart disease.GENOMICS,114(6).
MLA	Cheng, Q,et al."Structural and functional dysbiosis of gut microbiota in Tibetan subjects with coronary heart disease".GENOMICS 114.6(2022).