Phycocyanin: Anti-inflammatory effect and mechanism

doi:10.1016/j.biopha.2022.113362

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 海岸带生物学与生物资源利用重点实验室

	Phycocyanin: Anti-inflammatory effect and mechanism
	Liu, Runze 2; Qin, Song 1,2; Li, Wenjun 1,2
刊名	BIOMEDICINE & PHARMACOTHERAPY
	2022-09-01
卷号	153 页码:10
关键词	Phycocyanin Phycocyanobilin Inflammation Signal pathway Heme oxygenase 1 Kelch-like ECH-associated protein 1
ISSN号	0753-3322
DOI	10.1016/j.biopha.2022.113362
通讯作者	Li, Wenjun(wjli@yic.ac.cn)
英文摘要	As the host defense response to various injuries and pathogens in the body, inflammation can remove damaged cells and pathogens in the host organism and protect the body. However, excessive inflammation may cause damage to normal tissue cells while removing pathogens, which in turn cause numerous inflammatory diseases and adversely affect the human health. Phycocyanin is an active substance extracted from algae; it has outstanding antioxidant and anti-inflammatory activities, and can effectively inhibit various diseases caused by inflammation. This review systematically summarizes recent applications of phycocyanin against various inflammatory diseases in lung, liver, cardiovascular, and cerebrovascular systems. In addition, possible antiinflammatory action pathways of phycocyanin are reviewed to canvass the anti-inflammatory mechanism. At last, based on the existing research, phycocyanobilin in phycocyanin is proposed as a bilirubin analog by inducing heme oxygenase 1 in vivo to suppress inflammation.
WOS关键词	C-PHYCOCYANIN ; HEME OXYGENASE-1 ; SPIRULINA-PLATENSIS ; REDUCES INFLAMMATION ; BILIRUBIN ; ACTIVATION ; IMMUNE ; INJURY ; EXPRESSION ; APOPTOSIS
WOS研究方向	Research & Experimental Medicine ; Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000850076300002
资助机构	National Key Research and Development Program of China
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/31682]
专题	海岸带生物学与生物资源利用重点实验室
通讯作者	Li, Wenjun
作者单位	1.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Liu, Runze,Qin, Song,Li, Wenjun. Phycocyanin: Anti-inflammatory effect and mechanism[J]. BIOMEDICINE & PHARMACOTHERAPY,2022,153:10.
APA	Liu, Runze,Qin, Song,&Li, Wenjun.(2022).Phycocyanin: Anti-inflammatory effect and mechanism.BIOMEDICINE & PHARMACOTHERAPY,153,10.
MLA	Liu, Runze,et al."Phycocyanin: Anti-inflammatory effect and mechanism".BIOMEDICINE & PHARMACOTHERAPY 153(2022):10.