Multiscale biomechanics and mechanotransduction from liver fibrosis to cancer

doi:10.1016/j.addr.2022.114448

	Multiscale biomechanics and mechanotransduction from liver fibrosis to cancer
	Li N(李宁); Zhang XY(张晓宇); Zhou J(周瑾); Li W(李旺); Shu XY(舒芯钰); Wu Y(武亿); Long M(龙勉)
刊名	ADVANCED DRUG DELIVERY REVIEWS
	2022-09
卷号	188 页码:114448
关键词	Liver tissue stiffness Shear stress Hydrostatic pressure Hepatocytes Hepatocellular carcinoma Liver sinusoidal endothelial cells Hepatic stellate cells Mechanotransduction pathways Mechanomedicine Drug design and delivery
ISSN号	0169-409X
DOI	10.1016/j.addr.2022.114448
英文摘要	A growing body of multiscale biomechanical studies has been proposed to highlight the mechanical cues in the development of hepatic fibrosis and cancer. At the cellular level, changes in mechanical microen-vironment induce phenotypic and functional alterations of hepatic cells, initiating a positive feedback loop that promotes liver fibrogenesis and hepatocarcinogenesis. Tumor mechanical microenvironment of hepatocellular carcinoma facilitates tumor cell growth and metastasis, and hinders the drug delivery and immunotherapy. At the molecular level, mechanical forces are sensed and transmitted into hepatic cells via allosteric activation of mechanoreceptors on the cell membrane, leading to the activation of var-ious mechanotransduction pathways including integrin and YAP signaling and then regulating cell func-tion. Thus, the application of mechanomedicine concept in the treatment of liver diseases is promising for rational design and cell-specific delivery of therapeutic drugs. This review mainly discusses the correla-tion between biomechanical cues and liver diseases from the viewpoint of mechanobiology.(c) 2022 Elsevier B.V. All rights reserved.
学科主题	Pharmacology & Pharmacy
分类号	一类
语种	英语
WOS记录号	WOS:000853367300001
资助机构	National Natural Science Founda- tion of China [32130061, 31627804, 31870930] ; Scientific Instrument Developing Project of Chinese Academy of Sciences [GJJSTU20220002, GJJSTU20190005]
其他责任者	Long, M (corresponding author), Chinese Acad Sci, Inst Mech, Beijing 100190, Peoples R China.
内容类型	期刊论文
源URL	[http://dspace.imech.ac.cn/handle/311007/90140]
专题	力学研究所_国家微重力实验室
作者单位	1.Chinese Acad Sci, Inst Mech, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Natl Micrograv Lab, Ctr Biomech & Bioengn, Key Lab Micrograv, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Li N,Zhang XY,Zhou J,et al. Multiscale biomechanics and mechanotransduction from liver fibrosis to cancer[J]. ADVANCED DRUG DELIVERY REVIEWS,2022,188:114448.
APA	李宁.,张晓宇.,周瑾.,李旺.,舒芯钰.,...&龙勉.(2022).Multiscale biomechanics and mechanotransduction from liver fibrosis to cancer.ADVANCED DRUG DELIVERY REVIEWS,188,114448.
MLA	李宁,et al."Multiscale biomechanics and mechanotransduction from liver fibrosis to cancer".ADVANCED DRUG DELIVERY REVIEWS 188(2022):114448.