Lipidomic analysis probes lipid coronas on hydrophilic nanoparticles from natural lung surfactant

doi:10.1039/d2en00653g

CORC > 力学研究所 > 中国科学院力学研究所 > 非线性力学国家重点实验室

	Lipidomic analysis probes lipid coronas on hydrophilic nanoparticles from natural lung surfactant
	Bai, Xuan ; Lam, Sin Man 5,6; Nie PC(聂鹏程); Xu, Ming 2,3; Liu, Sijin 2,3; Shui, Guanghou 3,6; Hu, Guoqing
刊名	ENVIRONMENTAL SCIENCE-NANO
	2022-09-26
ISSN号	2051-8153
DOI	10.1039/d2en00653g
英文摘要	The large respiratory surface and high permeability make the lung promising in drug delivery of inhaled nanoparticles (NPs) as a portal and susceptible to nanosized airborne pollutions. Inhaled NPs first interact with the lung surfactant (LS) after depositing in the lung, where NPs tend to adsorb the LS molecules to form a biomolecular corona on their surface. Despite the extensive studies of protein coronas from blood plasma or serum, lipid coronas that are constituted by LS molecules are rarely investigated. Herein, we combine high-performance liquid chromatography-mass spectrometry and molecular dynamics simulation to unravel how a lipid corona is formed on hydrophilic NPs from a natural LS. Experiments demonstrate that positive surface charge, long incubation time, and external sonication can promote the formation of a complete lipid corona with compositions different from the bulk LS. Complementary to the experiments, molecular simulations indicate that the surface charge of NPs plays a vital role in the interactions of NPs with both zwitterionic and anionic lipids, which determines the wrap of the LS bilayer on the NP. In addition, the difference in the lipid composition between the corona and the bulk LS is caused by the affinity of NPs with lipids and the intrinsic structure of lipids. These results suggest that it is possible to control the formation and composition of lipid coronas on hydrophilic NPs by tuning the surface coating of NPs and incubation conditions.
学科主题	Chemistry, Multidisciplinary ; Environmental Sciences ; Nanoscience & Nanotechnology
分类号	一类
语种	英语
WOS记录号	WOS:000864813400001
资助机构	National Natural Science Foundation of China [11832017] ; Chinese Academy of Sciences Strategic Priority Research Program [XDB22040403] ; National Key R&D Program of China [2018YFA0800901, 2018YFA0506900] ; China National Postdoctoral Program for In11ative Talents [BX20200298]
其他责任者	Hu, GQ (corresponding author), Zhejiang Univ, State Key Lab Fluid Power & Mechatron Syst, Dept Engn Mech, Hangzhou, Peoples R China. ; Shui, GH (corresponding author), Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing, Peoples R China. ; Shui, GH (corresponding author), Univ Chinese Acad Sci, Beijing, Peoples R China.
内容类型	期刊论文
源URL	[http://dspace.imech.ac.cn/handle/311007/90161]
专题	力学研究所_非线性力学国家重点实验室
作者单位	1.Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing, Peoples R China 4.LipidALL Technol Co Ltd, Changzhou, Jiangsu, Peoples R China 5.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing, Peoples R China 6.Zhejiang Univ, State Key Lab Fluid Power & Mechatron Syst, Dept Engn Mech, Hangzhou, Peoples R China
推荐引用方式 GB/T 7714	Bai, Xuan,Lam, Sin Man,Nie PC,et al. Lipidomic analysis probes lipid coronas on hydrophilic nanoparticles from natural lung surfactant[J]. ENVIRONMENTAL SCIENCE-NANO,2022.
APA	Bai, Xuan.,Lam, Sin Man.,聂鹏程.,Xu, Ming.,Liu, Sijin.,...&Hu, Guoqing.(2022).Lipidomic analysis probes lipid coronas on hydrophilic nanoparticles from natural lung surfactant.ENVIRONMENTAL SCIENCE-NANO.
MLA	Bai, Xuan,et al."Lipidomic analysis probes lipid coronas on hydrophilic nanoparticles from natural lung surfactant".ENVIRONMENTAL SCIENCE-NANO (2022).