Heterogeneous Nanostructures Cause Anomalous Diffusion in Lipid Monolayers

doi:10.1021/acsnano.2c04089

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	Heterogeneous Nanostructures Cause Anomalous Diffusion in Lipid Monolayers
	Liu Y(刘杨); Zheng X(郑旭); Guan DS(关东石); Jiang XK(蒋玺恺); Hu GQ(胡国庆)
刊名	ACS NANO
	2022-12
关键词	Anomalous diffusion Lipid membrane Nanodomain Anomalous yet Brownian Heterogeneity
ISSN号	1936-0851
DOI	10.1021/acsnano.2c04089
英文摘要	The diffusion and mobility in biomembranes are crucial for various cell functions; however, the mechanisms involved in such processes remain ambiguous due to the complex membrane structures. Herein, we investigate how the heterogeneous nanostructures cause anomalous diffusion in dipalmitoylphosphatidylcholine (DPPC) monolayers. By identifying the existence of condensed nanodomains and clarifying their impact, our findings renew the understanding of the hydrodynamic description and the statistical feature of the diffusion in the monolayers. We find a universal characteristic of the multistage mean square displacement (MSD) with an intermediate crossover, signifying two membrane viscosities at different scales: the short-time scale describes the local fluidity and is independent of the nominal DPPC density, and the long-time scale represents the global continuous phase taking into account nanodomains and increases with DPPC density. The constant short-time viscosity reflects a dynamic equilibrium between the continuous fluid phase and the condensed nanodomains in the molecular scale. Notably, we observe an anomalous yet Brownian phenomenon exhibiting an unusual double-peaked displacement probability distribution (DPD), which is attributed to the net dipolar repulsive force from the heterogeneous nanodomains around the microdomains. The findings provide physical insights into the transport of membrane inclusions that underpin various biological functions and drug deliveries.
学科主题	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
分类号	一类
语种	英语
WOS记录号	WOS:000861379100001
资助机构	National Natural Science Foundation of China [11832017, 12072350, 11972351, 12102456] ; Chinese Academy of Sciences Key Research Program of Frontier Sciences [QYZDB-SSW-JSC036] ; Chinese Academy of Sciences Strategic Priority Research Program [XDB22040403]
其他责任者	Hu, GQ (corresponding author), Zhejiang Univ, Dept Engn Mech, State Key Lab Fluid Power & Mechatron Syst, Hangzhou 310027, Peoples R China.
内容类型	期刊论文
源URL	[http://dspace.imech.ac.cn/handle/311007/90133]
专题	力学研究所_非线性力学国家重点实验室
作者单位	1.Zhejiang Univ, Dept Engn Mech, State Key Lab Fluid Power & Mechatron Syst, Hangzhou 310027, Peoples R China 2.China Univ Min & Technol, Frontier Sci Res Ctr Fluidized Min Deep Undergrou, Xuzhou 221116, Jiangsu, Peoples R China 3.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech LNM, Beijing Key Lab Engn Construct & Mechanobiol, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Liu Y,Zheng X,Guan DS,et al. Heterogeneous Nanostructures Cause Anomalous Diffusion in Lipid Monolayers[J]. ACS NANO,2022.
APA	刘杨,郑旭,关东石,蒋玺恺,&胡国庆.(2022).Heterogeneous Nanostructures Cause Anomalous Diffusion in Lipid Monolayers.ACS NANO.
MLA	刘杨,et al."Heterogeneous Nanostructures Cause Anomalous Diffusion in Lipid Monolayers".ACS NANO (2022).