A novel chitosan and polydopamine interlinked bioactive coating for metallic biomaterials

doi:10.1007/s10856-022-06688-x

CORC > 金属研究所 > 中国科学院金属研究所

	A novel chitosan and polydopamine interlinked bioactive coating for metallic biomaterials
	Eren,Eri?en Deniz 3,4; Guisong,Gu 2; Mingming,Liu 1; Bingchun,Zhang 3; Ke,Yang 3; Shanshan,Chen 3
刊名	Journal of Materials Science: Materials in Medicine
	2022-09-23
卷号	33 期号:10
DOI	10.1007/s10856-022-06688-x
通讯作者	Ke,Yang(kyang@imr.ac.cn) ; Shanshan,Chen(sschen@imr.cn.cn)
英文摘要	AbstractChitosan coatings have shown good bioactive properties such as antibacterial and antiplatelet properties, especially on blood-contacted biomedical materials. However, as blood-contacted biomedical device, the intravascular metal stent has a burden with adverse effects on the structural integrity, such as mechanical load during implantation and substrate degradation if a biodegradable metal is used as the substrate. It is unquestionably true that the structural integrity of the coated stent is essential. The adhesion strength between the coating and the substrate positively affects it. Silane and polydopamine (PDA) interstitial layers have been investigated to improve the corrosion resistance, biosafety and adhesion strength. This work addressed this challenge by using PDA as an intermediate and glutaraldehyde as a linking agent to establish a strong link between the polymer coating and the intermediate coating. Compared with PDA-only and glutaraldehyde-linked silane layer, the novel coating displayed a notable increase in adhesion. When compared with the bare Ni-free stainless steel, the performance of the novel coating was not significantly different. This novel chitosan film on the glutaraldehyde linked-PDA interface can be applied to various metallic substrates where synergic bioactive and anticorrosive effects of PDA interstitial coating and chitosan are needed.Graphical abstract
语种	英语
出版者	Springer US
WOS记录号	BMC:10.1007/S10856-022-06688-X
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/175003]
专题	金属研究所_中国科学院金属研究所
通讯作者	Ke,Yang; Shanshan,Chen
作者单位	1.Shenyang University 2.University of Science and Technology of Liaoning 3.Institute of Metal Research, Chinese Academy of Sciences; Shi-changxu Innovation Center for Advanced Materials 4.University of Science and Technology of China; School of Material Science and Engineering
推荐引用方式 GB/T 7714	Eren,Eri?en Deniz,Guisong,Gu,Mingming,Liu,et al. A novel chitosan and polydopamine interlinked bioactive coating for metallic biomaterials[J]. Journal of Materials Science: Materials in Medicine,2022,33(10).
APA	Eren,Eri?en Deniz,Guisong,Gu,Mingming,Liu,Bingchun,Zhang,Ke,Yang,&Shanshan,Chen.(2022).A novel chitosan and polydopamine interlinked bioactive coating for metallic biomaterials.Journal of Materials Science: Materials in Medicine,33(10).
MLA	Eren,Eri?en Deniz,et al."A novel chitosan and polydopamine interlinked bioactive coating for metallic biomaterials".Journal of Materials Science: Materials in Medicine 33.10(2022).