A micellar HPLC method for simultaneous determination of six active ingredients in cold compound preparations

doi:10.1080/10826076.2019.1625375

	A micellar HPLC method for simultaneous determination of six active ingredients in cold compound preparations
	Duan, Xiaoyun 1; Liu, Xiaofeng 1; Dong, Yue 3; Zhang, Jing 3; He, Shujuan 3; Uhagaze, D. Serge 3; Yang, Fatang 3; Dong, Yuming 2,3
刊名	JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
	2019-06-19
卷号	42 期号:15-16 页码:485-493
关键词	Caffeine chlorpheniramine maleate cold compound preparations diphenhydramine and dextromethorphan Micellar per aqueous liquid paracetamol polyoxyethylene lauryl ether pseudoephedrine
ISSN号	1082-6076
DOI	10.1080/10826076.2019.1625375
英文摘要	The first use of micellar per aqueous liquid chromatographic method to determine chlorpheniramine, pseudoephedrine hydrochloride, caffeine, paracetamol, dextromethorphan and diphenhydramine in cold compound preparations within 30min. The established method used an ATEO-CN column (250mm x 4.6mm, 5 mu m) as stationary phase. The mobile phase consisted of aqueous solution (0.003 mol/L Brij-35 and 0.02 mol/L potassium dihydrogen phosphate) -acetonitrile(96: 4, v/v) at pH 3.0. The possible separation mechanism of chromatographic system was also discussed. The method was successfully validated including linearity (r(2) > 0.9984) and range (1.30-2.2 x 10(-3)mg/L), limit of quantitation (0.73-2.60 mu g/mL), limit of detection (0.14-0.92 mu g/mL), accuracy (86.1-111.2%), intra and inter precision (RSD < 7.1%, and < 4.2%). The established method can be used for quality control and routine monitoring of common cold preparations.
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	TAYLOR & FRANCIS INC
WOS记录号	WOS:000473050800001
状态	已发表
内容类型	期刊论文
源URL	[http://119.78.100.223/handle/2XXMBERH/31792]
专题	生命科学与工程学院
通讯作者	Dong, Yuming
作者单位	1.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou, Gansu, Peoples R China 2.Lanzhou Univ Techcomp China Ltd, Joint Lab Pharmaceut Anal, Lanzhou, Gansu, Peoples R China 3.Lanzhou Univ, Sch Pharm, Inst Pharmaceut Anal, Lanzhou, Gansu, Peoples R China
推荐引用方式 GB/T 7714	Duan, Xiaoyun,Liu, Xiaofeng,Dong, Yue,et al. A micellar HPLC method for simultaneous determination of six active ingredients in cold compound preparations[J]. JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES,2019,42(15-16):485-493.
APA	Duan, Xiaoyun.,Liu, Xiaofeng.,Dong, Yue.,Zhang, Jing.,He, Shujuan.,...&Dong, Yuming.(2019).A micellar HPLC method for simultaneous determination of six active ingredients in cold compound preparations.JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES,42(15-16),485-493.
MLA	Duan, Xiaoyun,et al."A micellar HPLC method for simultaneous determination of six active ingredients in cold compound preparations".JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES 42.15-16(2019):485-493.