The recombinant protein combined vaccine based on the fragment C of tetanus toxin and the cross-reacting material 197

doi:10.1007/s00253-021-11139-8

	The recombinant protein combined vaccine based on the fragment C of tetanus toxin and the cross-reacting material 197
	Chai, Pengdi 1,2; Pu, Xiuying 2; Ge, Jun 1; Ren, Sulin 1; Xia, Xiaoyu 1,2; Luo, Amiao 2; Wang, Shiwei 1; Wang, Xiaodong 1; Li, Jianqiang 1
刊名	APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
	2021-02
卷号	105 期号:4 页码:1683-1692
关键词	Tetanus Diphtheria The fragment C CRM197 A booster vaccine
ISSN号	0175-7598
DOI	10.1007/s00253-021-11139-8
英文摘要	Diphtheria and tetanus toxoids and acellular pertussis (DTaP) vaccines were widely used since 1940s. The exceptional success of childhood vaccination is undisputed. However, the anti-diphtheria and tetanus antibody will decrease with the increase of age in human body. A boosting vaccine for tetanus and diphtheria in adult is recommended by WHO. Recombinant protein vaccine has the advantages of single component and high safety, which is one of the directions to develop boosting vaccines. Therefore, in this study, we evaluated a recombinant TTc and CRM197 combination vaccine (RTCV) that uses the fragment C (TTc) of tetanus toxin and the cross-reacting material 197 (CRM197) of the diphtheria toxin mutant. Our results displayed that RTCV (composed of 10 mu g/mL TTc, 20 mu g/mL CRM197 antigens, and 500 mu g/mL aluminum adjuvants) could induce high levels of IgG and IgG1 antibody in mice, which were similar as those induced by DTaP. These results will provide technical support for a novel boosting vaccine against diphtheria and tetanus.
WOS研究方向	Biotechnology & Applied Microbiology
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000612600900005
内容类型	期刊论文
源URL	[http://ir.lut.edu.cn/handle/2XXMBERH/147317]
专题	生命科学与工程学院
通讯作者	Li, Jianqiang
作者单位	1.Jiangsu Theravac Biopharmaceut CO Ltd, 699-18 Xuanwu St, Nanjing 210042, Peoples R China; 2.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730050, Peoples R China
推荐引用方式 GB/T 7714	Chai, Pengdi,Pu, Xiuying,Ge, Jun,et al. The recombinant protein combined vaccine based on the fragment C of tetanus toxin and the cross-reacting material 197[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2021,105(4):1683-1692.
APA	Chai, Pengdi.,Pu, Xiuying.,Ge, Jun.,Ren, Sulin.,Xia, Xiaoyu.,...&Li, Jianqiang.(2021).The recombinant protein combined vaccine based on the fragment C of tetanus toxin and the cross-reacting material 197.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,105(4),1683-1692.
MLA	Chai, Pengdi,et al."The recombinant protein combined vaccine based on the fragment C of tetanus toxin and the cross-reacting material 197".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 105.4(2021):1683-1692.